Cancer is a major threat to human health. Among various treatment methods, precision
therapy has received significant attention since the inception, due to its ability to efficiently …

Tumor cellular metabolism exhibits distinguishing features that collectively enhance
biomass synthesis while maintaining redox balance and cellular homeostasis. These …

Peroxisomes are essential metabolic organelles, well known for their roles in the
metabolism of complex lipids and reactive ionic species. In the past 10 years, peroxisomes …

Peroxisomes are metabolic organelles involved in lipid metabolism and cellular redox
balance. Peroxisomal function is central to fatty acid oxidation, ether phospholipid synthesis …

The immune response is essential to protect organisms from infection and an altered self. An
organism's overall metabolic status is now recognized as an important and long-overlooked …

Simple Summary KRAS plays an important role in transmitting signals from growth factors on
the outside of the cell to the cell nucleus. It regulates cell proliferation, growth, and survival …

Melanomas reprogram their metabolism to rapidly adapt to therapy-induced stress
conditions, allowing them to persist and ultimately develop resistance. We report that a …

Metabolism is emerging as a central influencer of multiple disease states in humans.
Peroxisomes are central metabolic organelles whose decreased function gives rise to …

Ether-lipids (EL) are specific lipids bearing a characteristic sn-1 ether bond. Depending on
the ether or vinyl-ether nature of this bond, they are present as alkyl-or alkenyl-EL …

PI5P4Ks are a class of phosphoinositide kinases that phosphorylate PI-5-P to PI-4, 5-P 2.
Distinct localization of phosphoinositides is fundamental for a multitude of cellular functions …