Context Antiresorptive therapy significantly reduces fracture risk in patients with benign bone
disease and skeletal-related events (SREs) in patients with bone metastases (BM) …

Simple Summary Spine metastases are a common life-threatening complication of
advanced-stage malignancies and often result in poor prognosis. Symptomatic spine …

Osteonecrosis of the jaw (ONJ) is a rare but serious adverse event associated with
antiresorptive treatment. There is little evidence regarding the incidence of ONJ among …

Background Bone metastasis occurs in nearly 70% of patients with metastatic prostate
cancer (PCa), and represents the leading cause of death in patients with PCa. Emerging …

Simple Summary In recent years, therapeutic options for patients with metastatic prostate
cancer have improved significantly. However, the efficacy of current immunotherapy …

Objective The purpose of this study was to evaluate the efficacy of denosumab treatment in
patients with rheumatoid arthritis (RA). Methods The Medline, Embase and Cochrane …

The skeleton is a common site for cancer metastases with the bone microenvironment
providing the appropriate conditions for cancer cell colonization. Once in bone, cancer cells …

It is of great challenges to repair bone defect and prevent tumor recurrence in bone tumors
postoperative treatment. Bone scaffolds loaded with zoledronate (ZOL) are expected to …

Medication-related osteonecrosis of the jaw (MRONJ) represents an adverse side effect of
antiresorptive and antiangiogenic medications. It is associated with impaired quality of life …

Cancer is among the leading causes of death from noncommunicable diseases worldwide.
Based on 2015 to 2017 data, approximately 39.5% of men and women will be diagnosed …