Skeletal muscle atrophy occurs in many chronic diseases and disuse conditions. Its severity
reduces patient recovery, independence and quality of life. The discovery of two muscle …

Anabolic and catabolic pathways regulating skeletal muscle m... : Current Opinion in Clinical
Nutrition & Metabolic Care Anabolic and catabolic pathways regulating skeletal muscle mass …

The skeletal muscle phenotype is subject to considerable malleability depending on use.
Lowintensity endurance type exercise leads to qualitative changes of muscle tissue …

Astrocytes are the most abundant glia cell type in the central nervous system (CNS), and are
known to constitute heterogeneous populations that differ in their morphology, gene …

For over 10 years, we have known that the activation of the mammalian target of rapamycin
complex 1 (mTORC1) has correlated with the increase in skeletal muscle size and strength …

Loss of muscle mass and function occurs in various diseases. Myostatin blocking can
attenuate muscle loss, but downstream signaling is not well known. Therefore, to elucidate …

Type 1 diabetes, if poorly controlled, leads to skeletal muscle atrophy, decreasing the quality
of life. We aimed to search highly responsive genes in diabetic muscle atrophy in a common …

Myostatin (MSTN) is a member of the transforming growth factor-β superfamily of cytokines
and is a negative regulator of skeletal muscle mass. Compared with MSTN+/+ mice, the …

Tamoxifen, a selective estrogen-receptor modulator, is widely used in mouse models to
temporally control gene expression but is also known to affect body composition. We report …

Aims/hypothesis Protein tyrosine phosphatase 1B (PTP1B) is a key negative regulator of
insulin signalling. Hepatic PTP1B deficiency, using the Alb-Cre promoter to drive Ptp1b …