Early life stress (ELS), such as abuse and neglect during childhood, can lead to psychiatric
disorders in later life. Previous studies have suggested that ELS can cause profound …

Background Prenatal maternal stress is increasingly recognized as a risk factor for offspring
mental health challenges. DNA methylation may be a mechanism, but few studies directly …

Background Maternal stress before, during and after pregnancy has profound effects on the
development and lifelong function of the infant's neurocognitive development. We …

Prenatal stress and poor maternal mental health are associated with adverse offspring
outcomes; however, the biological mechanisms are unknown. Epigenetic modification has …

Depression is one of the most common mental disorders and has caused an overwhelming
burden on world health. Abundant studies have suggested that early life stress may grant …

Susceptibility to psychiatric disorders seems to be influenced by environmental disturbances
throughout all stages of life. Epigenetics is described as a key “bridge” between gene and …

Prenatal environment significantly influences mammalian fetal development and adverse in
utero conditions have life-long consequences for the offspring health. Research has …

Epigenetic mechanisms such as DNA methylation (DNAm) have been associated with stress
responses and increased vulnerability to depression. Abnormal DNAm is observed in …

Purpose The Little in Norway (LiN) project is a cross-disciplinary prospective longitudinal
study starting in pregnancy. It was set up to investigate maternal and paternal mental health …

Background: Maternal prenatal stress is associated with physiologic and adverse mental
health outcomes in the offspring, but the underlying biologic mechanisms are unknown. We …