A systems biology view of blood vessel growth and remodelling

EA Logsdon, SD Finley, AS Popel… - Journal of cellular and …, 2014 - Wiley Online Library
Blood travels throughout the body in an extensive network of vessels–arteries, veins and
capillaries. This vascular network is not static, but instead dynamically remodels in response …

[PDF][PDF] Muscle satellite cell cross-talk with a vascular niche maintains quiescence via VEGF and notch signaling

M Verma, Y Asakura, BSR Murakonda, T Pengo… - Cell stem cell, 2018 - cell.com
Skeletal muscle is a complex tissue containing tissue resident muscle stem cells (satellite
cells)(MuSCs) important for postnatal muscle growth and regeneration. Quantitative analysis …

[HTML][HTML] A systematic review and meta-analysis of preanalytical factors and methodological differences influencing the measurement of circulating vascular endothelial …

U Sjöbom, AK Nilsson, H Gyllensten, A Hellström… - Plos one, 2022 - journals.plos.org
Background Intraocular treatment with antibodies targeting vascular endothelial growth
factor (anti-VEGF) inhibits pathological vessel growth in adults and preterm infants …

Neural crest migration is driven by a few trailblazer cells with a unique molecular signature narrowly confined to the invasive front

R McLennan, LJ Schumacher, JA Morrison… - …, 2015 - journals.biologists.com
Neural crest (NC) cell migration is crucial to the formation of peripheral tissues during
vertebrate development. However, how NC cells respond to different microenvironments to …

[HTML][HTML] VEGFR1 promotes cell migration and proliferation through PLCγ and PI3K pathways

JC Weddell, S Chen, PI Imoukhuede - NPJ systems biology and …, 2017 - nature.com
The ability to control vascular endothelial growth factor (VEGF) signaling offers promising
therapeutic potential for vascular diseases and cancer. Despite this promise, VEGF-targeted …

Sustained release of multicomponent platelet‐rich plasma proteins from hydrolytically degradable PEG hydrogels

E Jain, S Sheth, A Dunn, SP Zustiak… - Journal of Biomedical …, 2017 - Wiley Online Library
Abstract Platelet‐rich plasma (PRP), an autologous blood derived product is a concentrated
mix of multiple growth factors and cytokines. Direct injections of PRP are clinically used for …

Vascular endothelial growth factor isoform-B stimulates neurovascular repair after ischemic stroke by promoting the function of pericytes via vascular endothelial …

N Jean LeBlanc, R Guruswamy, A ElAli - Molecular Neurobiology, 2018 - Springer
Ischemic stroke triggers endogenous angiogenic mechanisms, which correlates with longer
survival in patients. As such, promoting angiogenesis appears to be a promising approach …

[HTML][HTML] Anti-VEGF drugs dynamics: relevance for clinical practice

D Veritti, V Sarao, G Gorni, P Lanzetta - Pharmaceutics, 2022 - mdpi.com
Background: A drug and disease assessment model was used to evaluate the impact of
different treatment regimens on intravitreal ranibizumab, bevacizumab, aflibercept, and …

Mathematical model predicts effective strategies to inhibit VEGF-eNOS signaling

Q Wu, SD Finley - Journal of Clinical Medicine, 2020 - mdpi.com
The endothelial nitric oxide synthase (eNOS) signaling pathway in endothelial cells has
multiple physiological significances. It produces nitric oxide (NO), an important vasodilator …

[HTML][HTML] Compartment model predicts VEGF secretion and investigates the effects of VEGF trap in tumor-bearing mice

SD Finley, M Dhar, AS Popel - Frontiers in oncology, 2013 - frontiersin.org
Angiogenesis, the formation of new blood vessels from existing vasculature, is important in
tumor growth and metastasis. A key regulator of angiogenesis is vascular endothelial growth …