Highlights•Our limited arsenal of antifungals is threatened by drug-resistant fungal
pathogens.•Inherent resistance is when all strains of a species show antifungal …

Fluconazole has characteristics that make it widely used in the clinical treatment of C.
albicans infections. However, fluconazole has only a fungistatic activity in C. albicans …

Knowing the full set of essential genes for a given organism provides important information
about ways to promote, and to limit, its growth and survival. For many non-model organisms …

The essential oil from Rosmarinus officinalis L., a composite mixture of plant-derived
secondary metabolites, exhibits antifungal activity against virulent candidal species. Here …

Fluconazole (FLC) is widely used to prevent and treat invasive fungal infections. However,
FLC is a fungistatic agent, allowing clinical FLC-susceptible isolates to tolerate FLC. Making …

Morphological changes are critical for the virulence of a range of plant and human fungal
pathogens. Candida albicans is a major human fungal pathogen whose ability to switch …

Candida albicans is a leading cause of death due to fungal infection. Treatment of systemic
candidiasis often relies on echinocandins, which disrupt cell wall synthesis. Resistance is …

Increased morbidity and mortality of candidiasis are a notable threat to the
immunocompromised patients. At present, the types of drugs available to treat C. albicans …

The Candida genus encompasses a diverse group of ascomycete fungi that have captured
the attention of the scientific community, due to both their role in pathogenesis and emerging …

An essential gene encodes for a cellular function that is required for viability. Although
viability is a straightforward phenotype to analyze in yeast, defining a gene as essential is …