Cell-derived extracellular matrices (CD-ECMs) captured increasing attention since the first
studies in the 1980s. The biological resemblance of CD-ECMs to their in vivo counterparts …

Tissue engineering and regenerative medicine have shown potential in the repair and
regeneration of tissues and organs via the use of engineered biomaterials and scaffolds …

Osteoarthritis (OA) is a widespread chronic degenerative joint disease characterized by the
degeneration of articular cartilage or inflamed joints. Our findings indicated that treatment …

The effectiveness of existing tissue‐engineering cartilage (TEC) is known to be hampered
by weak integration of biocompatibility, biodegradation, mechanical strength, and …

Silk fibroin (SF) is considered biocompatible and biodegradable for osteochondral repair.
However, it lacks a bioactive domain for cell adhesion, proliferation and differentiation …

Cartilage, especially articular cartilage, is a unique connective tissue consisting of
chondrocytes and cartilage matrix that covers the surface of joints. It plays a critical role in …

Tissue development, wound healing, pathogenesis, regeneration, and homeostasis rely
upon coordinated and dynamic spatial and temporal remodeling of extracellular matrix …

Cell-derived extracellular matrix (ECM) has been employed as scaffolds for tissue
engineering, creating a biomimetic microenvironment that provides physical, chemical and …

Owing to its high disability and mortality rates, stroke has been the second leading cause of
death worldwide. Since the pathological mechanisms of stroke are not fully understood …

Cell dedifferentiation is the process by which cells grow reversely from a partially or
terminally differentiated stage to a less differentiated stage within their own lineage. This …