Antibodies are essential molecules for diagnosis and treatment of diseases caused by
pathogens and their toxins. Antibodies were integrated in our medical repertoire against …

With six approved products and more than 60 candidates in clinical testing, human
monoclonal antibody discovery by phage display is well established as a robust and reliable …

Clostridium botulinum C3 exoenzyme (C3bot) exclusively inhibits RhoA, B and C by ADP-
ribosylation and is therefore used as a cell-permeable tool for investigating the cellular role …

The type III intermediate filament protein vimentin was recently identified to mediate binding
and uptake of Clostridium botulinum C3 exoenzyme (C3bot) in two cell lines. Here, we used …

The Rho ADP-ribosylating C3 exoenzyme (C3bot) is a bacterial protein toxin devoid of a cell-
binding or-translocation domain. Nevertheless, C3 can efficiently enter intact cells, including …

Preservation of the excitability of spiral ganglion neurons (SGN) may contribute to an
improved speech perception after cochlear implantation. Thus, the application of exogenous …

Rho GTPases activity in tear fluid as well as ocular surface epithelium (OSEC) during
progression of Keratoconjunctivitis sicca (KCS) and their modulation with Rosuvastatin in …

Mono ADP-ribosylation is a common characteristic of bacterial toxins resulting to aberrant
activation or inactivation of target proteins. The C3 exoenzyme of Clostridium botulinum …

Background: Angiogenesis is an essential physiological process for growth and
maintenance of the body. Especially its role becomes indispendable during the embryonic …

The ADP-ribosyltransferase C3 exoenzyme from C. botulinum selectively inactivates Rho
and is therefore often used as an inhibitor for investigations on Rho signaling. Previous …