[HTML][HTML] The NLRP3 inflammasome in non-alcoholic fatty liver disease and steatohepatitis: Therapeutic targets and treatment

L Yu, W Hong, S Lu, Y Li, Y Guan, X Weng… - Frontiers in …, 2022 - frontiersin.org
Non-alcoholic fatty liver disease (NAFLD) is among the most prevalent primary liver
diseases worldwide and can develop into various conditions, ranging from simple steatosis …

[HTML][HTML] Promising nanocarriers to enhance solubility and bioavailability of cannabidiol for a plethora of therapeutic opportunities

L Grifoni, G Vanti, R Donato, C Sacco, AR Bilia - Molecules, 2022 - mdpi.com
In recent years, the interest in cannabidiol (CBD) has increased because of the lack of
psychoactive properties. However, CBD has low solubility and bioavailability, variable …

Emerging therapeutic potential of cannabidiol (CBD) in neurological disorders: a comprehensive review

K Singh, B Bhushan, DK Chanchal… - Behavioural …, 2023 - Wiley Online Library
Cannabidiol (CBD), derived from Cannabis sativa, has gained remarkable attention for its
potential therapeutic applications. This thorough analysis explores the increasing …

CB2 receptor in the CNS: From immune and neuronal modulation to behavior

W Grabon, S Rheims, J Smith, J Bodennec… - Neuroscience & …, 2023 - Elsevier
Despite low levels of cannabinoid receptor type 2 (CB2R) expression in the central nervous
system in human and rodents, a growing body of evidence shows CB2R involvement in …

Sex-dependent differences in the anxiolytic-like effect of cannabidiol in the elevated plus-maze

D Fabris, MC Carvalho, ML Brandão… - Journal of …, 2022 - journals.sagepub.com
Rationale: Cannabidiol (CBD), the major non-psychoactive constituent of cannabis, has
therapeutic potential for the treatment of anxiety. Most preclinical studies investigate only …

[HTML][HTML] Cannabidiol for the treatment of brain disorders: therapeutic potential and routes of administration

GTY Yau, W Tai, JC Arnold, HK Chan… - Pharmaceutical …, 2023 - Springer
The use of cannabidiol (CBD) for treating brain disorders has gained increasing interest.
While the mechanism of action of CBD in these conditions is still under investigation, CBD …

Statement on safety of cannabidiol as a novel food: data gaps and uncertainties

EFSA Panel on Nutrition, Novel Foods and Food … - EFSA …, 2022 - Wiley Online Library
Abstract The European Commission has determined that cannabidiol (CBD) can be
considered as a novel food (NF), and currently, 19 applications are under assessment at …

[HTML][HTML] A 2022 systematic review and meta-analysis of enriched therapeutic diets and nutraceuticals in canine and feline osteoarthritis

M Barbeau-Grégoire, C Otis, A Cournoyer… - International Journal of …, 2022 - mdpi.com
With osteoarthritis being the most common degenerative disease in pet animals, a very
broad panel of natural health products is available on the market for its management. The …

[HTML][HTML] In utero exposure to cannabidiol disrupts select early-life behaviors in a sex-specific manner

D Iezzi, A Caceres-Rodriguez, P Chavis… - Translational …, 2022 - nature.com
Cannabidiol (CBD), one of the main components of cannabis, is generally considered safe.
CBD crosses the placenta and its use during pregnancy is steadily increasing, the impact of …

An update on animal models of intervertebral disc degeneration and low back pain: exploring the potential of artificial intelligence to improve research analysis and …

M Alini, AD Diwan, WM Erwin, CB Little, J Melrose - JOR spine, 2023 - Wiley Online Library
Animal models have been invaluable in the identification of molecular events occurring in
and contributing to intervertebral disc (IVD) degeneration and important therapeutic targets …