The advancements in technology and manufacturing processes have allowed the
development of new derivatives, biosimilar or advanced improved versions for approved …

A defining characteristic of the immune system is the constant movement of many of its
constituent cells through the secondary lymphoid tissues, mainly the spleen and lymph …

The exact identification of B cell subsets is instrumental to understand their dynamics under
physiological and pathological conditions. Human memory B cells are currently identified …

The c-Myb transcription factor is crucial during definitive hematopoiesis. However, the
embryonic lethality of Myb traditional null mutations has precluded analysis of c-Myb …

BACKGROUND AND OBJECTIVES: Post-transplant lymphoproliferative disorder (PTLD)
following allogeneic hematopioetic stem cell transplantation (HSCT) is a fulminant disease …

Although it is clear that the final phases of B cell maturation occur after newly formed B cells
exit the bone marrow, the mechanisms underpinning the maturation, selection, and long …

Inflammation can predispose to myocardial infarction (MI), and mannan binding lectin (MBL)
promotes phagocytic clearance of inflammatory agents, but the predictive value of MBL …

Antibodies against allogeneic human leukocyte antigen (HLA) molecules are important
impediments to the success of different clinical procedures including transplantation and …

Leucocyte subpopulations in both lymphoid and myeloid lineages have a significant impact
on antitumor immune response. While radiation-induced lymphopenia is being studied …

Cellular homeostasis in the B cell compartment is strictly imposed to balance cell production
and cell loss. However, it is not clear whether B cell development in the bone marrow is an …