Targeting oxidative stress in disease: Promise and limitations of antioxidant therapy

HJ Forman, H Zhang - Nature Reviews Drug Discovery, 2021 - nature.com
Oxidative stress is a component of many diseases, including atherosclerosis, chronic
obstructive pulmonary disease, Alzheimer disease and cancer. Although numerous small …

Idiopathic pulmonary fibrosis: an update on pathogenesis

Q Mei, Z Liu, H Zuo, Z Yang, J Qu - Frontiers in Pharmacology, 2022 - frontiersin.org
Idiopathic pulmonary fibrosis (IPF) is a progressive, lethal fibrotic lung disease that occurs
primarily in middle-aged and elderly adults. It is a major cause of morbidity and mortality …

Role of JAK/STAT in interstitial lung diseases; molecular and cellular mechanisms

P Montero, J Milara, I Roger, J Cortijo - International journal of molecular …, 2021 - mdpi.com
Interstitial lung diseases (ILDs) comprise different fibrotic lung disorders characterized by
cellular proliferation, interstitial inflammation, and fibrosis. The JAK/STAT molecular pathway …

Therapeutic effects of green tea polyphenol (‒)-Epigallocatechin-3-Gallate (EGCG) in relation to molecular pathways controlling inflammation, oxidative stress, and …

D Mokra, M Joskova, J Mokry - International journal of molecular sciences, 2022 - mdpi.com
(‒)-Epigallocatechin-3-gallate (EGCG) is the most abundant polyphenol in green tea.
Thanks to multiple interactions with cell surface receptors, intracellular signaling pathways …

[HTML][HTML] Inhibition of ferroptosis and iron accumulation alleviates pulmonary fibrosis in a bleomycin model

Z Pei, Y Qin, X Fu, F Yang, F Huo, X Liang, S Wang… - Redox Biology, 2022 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disease characterized by
excessive proliferation of fibroblasts and excessive accumulation of extracellular matrix …

Oxidative stress-induced endothelial dysfunction in cardiovascular diseases

A Shaito, K Aramouni, R Assaf, A Parenti, A Orekhov… - 2022 - qspace.qu.edu.qa
Cardiovascular disease (CVD) is a major cause of mortality worldwide. A better
understanding of the mechanisms underlying CVD is key for better management or …

Fibrosis: types, effects, markers, mechanisms for disease progression, and its relation with oxidative stress, immunity, and inflammation

SA Antar, NA Ashour, ME Marawan… - International Journal of …, 2023 - mdpi.com
Most chronic inflammatory illnesses include fibrosis as a pathogenic characteristic.
Extracellular matrix (ECM) components build up in excess to cause fibrosis or scarring. The …

Research progress in the molecular mechanisms, therapeutic targets, and drug development of idiopathic pulmonary fibrosis

H Ma, X Wu, Y Li, Y Xia - Frontiers in Pharmacology, 2022 - frontiersin.org
Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease. Recent studies have
identified the key role of crosstalk between dysregulated epithelial cells, mesenchymal …

The Lung Microbiota Affects Pulmonary Inflammation and Oxidative Stress Induced by PM2.5 Exposure

S Wang, Q Zhou, Y Tian, X Hu - Environmental science & …, 2022 - ACS Publications
Fine particulate matter (PM2. 5) exposure causes respiratory diseases by inducing
inflammation and oxidative stress. However, the correlation between the pulmonary …

Molecular pathogenesis of pulmonary fibrosis, with focus on pathways related to TGF-β and the ubiquitin-proteasome pathway

N Inui, S Sakai, M Kitagawa - International journal of molecular sciences, 2021 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease. During
the past decade, novel pathogenic mechanisms of IPF have been elucidated that have …