With both catalytic and genetic functions, ribonucleic acid (RNA) is perhaps the most
pluripotent chemical species in molecular biology, and its functions are intimately linked to …

This review aims at juxtaposing common versus distinct structural and functional strategies
that are applied by aptamers, riboswitches, and ribozymes/DNAzymes. Focusing on recently …

The prediction of RNA three‐dimensional structures remains an unsolved problem. Here, we
report assessments of RNA structure predictions in CASP15, the first CASP exercise that …

Self-cleaving ribozymes were discovered 30 years ago, but their biological distribution and
catalytic mechanisms are only beginning to be defined. Each ribozyme family is defined by a …

The discovery of RNA-catalyzed phosphodiester bond cleavage by Cech and Altman in
1982− 1983 shattered the paradigm of protein-dependent biological catalysis and opened …

We present a brief overview of explicit solvent molecular dynamics (MD) simulations of
nucleic acids. We explain physical chemistry limitations of the simulations, namely, the …

We present a crystal structure at 2.3-Å resolution of the recently described nucleolytic
ribozyme twister. The RNA adopts a previously uncharacterized compact fold based on a …

HDV ribozymes catalyze their own scission from the transcript during rolling circle replication
of the hepatitis delta virus. In vitro selection of self-cleaving ribozymes from a human …

Most RNA folding studies have been performed under non-physiological conditions of high
concentrations (≥ 10 mM) of Mg2+ free, while actual cellular concentrations of Mg2+ free …

This book covers the emerging topic of DNA nanotechnology and DNA supramolecular
chemistry in its broader sense. By taking DNA out of its biological role, this biomolecule has …