Opportunities and challenges for machine learning-assisted enzyme engineering
Enzymes can be engineered at the level of their amino acid sequences to optimize key
properties such as expression, stability, substrate range, and catalytic efficiency─ or even to …
properties such as expression, stability, substrate range, and catalytic efficiency─ or even to …
A guide to artificial intelligence for cancer researchers
Artificial intelligence (AI) has been commoditized. It has evolved from a specialty resource to
a readily accessible tool for cancer researchers. AI-based tools can boost research …
a readily accessible tool for cancer researchers. AI-based tools can boost research …
The reactome pathway knowledgebase 2024
M Milacic, D Beavers, P Conley, C Gong… - Nucleic acids …, 2024 - academic.oup.com
Abstract The Reactome Knowledgebase (https://reactome. org), an Elixir and GCBR core
biological data resource, provides manually curated molecular details of a broad range of …
biological data resource, provides manually curated molecular details of a broad range of …
Oxidative cyclization reagents reveal tryptophan cation–π interactions
Methods for selective covalent modification of amino acids on proteins can enable a diverse
array of applications, spanning probes and modulators of protein function to proteomics …
array of applications, spanning probes and modulators of protein function to proteomics …
Will variants of uncertain significance still exist in 2030?
Summary In 2020, the National Human Genome Research Institute (NHGRI) made ten" bold
predictions," including that" the clinical relevance of all encountered genomic variants will be …
predictions," including that" the clinical relevance of all encountered genomic variants will be …
[HTML][HTML] Human coronavirus HKU1 recognition of the TMPRSS2 host receptor
The human coronavirus HKU1 spike (S) glycoprotein engages host cell surface sialoglycans
and transmembrane protease serine 2 (TMPRSS2) to initiate infection. The molecular basis …
and transmembrane protease serine 2 (TMPRSS2) to initiate infection. The molecular basis …
The power and pitfalls of AlphaFold2 for structure prediction beyond rigid globular proteins
Artificial intelligence-driven advances in protein structure prediction in recent years have
raised the question: has the protein structure-prediction problem been solved? Here, with a …
raised the question: has the protein structure-prediction problem been solved? Here, with a …
Data-centric foundation models in computational healthcare: A survey
The advent of foundation models (FMs) as an emerging suite of AI techniques has struck a
wave of opportunities in computational healthcare. The interactive nature of these models …
wave of opportunities in computational healthcare. The interactive nature of these models …
Predicting pathogenic protein variants
JA Marsh, SA Teichmann - Science, 2023 - science.org
Many of the genetic mutations that cause disease in humans occur in protein-coding
regions. Although the capacity to sequence DNA and identify these variants has …
regions. Although the capacity to sequence DNA and identify these variants has …
Artificial Intelligence in Oncology: Current Landscape, Challenges, and Future Directions
Artificial intelligence (AI) in oncology is advancing beyond algorithm development to
integration into clinical practice. This review describes the current state of the field, with a …
integration into clinical practice. This review describes the current state of the field, with a …