[HTML][HTML] Treatment strategies and outcomes for patients with EGFR-mutant non-small cell lung cancer resistant to EGFR tyrosine kinase inhibitors: focus on novel …

M Johnson, MC Garassino, T Mok, T Mitsudomi - Lung Cancer, 2022 - Elsevier
Tyrosine kinase inhibitors (TKIs) are the standard of care for patients with non-small cell lung
cancer (NSCLC) that harbor mutations of the epidermal growth factor receptor (EGFR) gene …

Acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non–small-cell lung cancers dependent on the epidermal growth factor receptor …

KSH Nguyen, S Kobayashi, DB Costa - Clinical lung cancer, 2009 - Elsevier
Abstract Most advanced Non–Small-cell lung cancers (NSCLCs) with activating epidermal
growth factor receptor (EGFR) mutations (exon 19 deletions or L858R) initially respond to …

[HTML][HTML] BIM mediates EGFR tyrosine kinase inhibitor-induced apoptosis in lung cancers with oncogenic EGFR mutations

DB Costa, B Halmos, A Kumar, ST Schumer… - PLoS …, 2007 - journals.plos.org
Background Epidermal growth factor receptor (EGFR) mutations are present in the majority
of patients with non-small cell lung cancer (NSCLC) responsive to the EGFR tyrosine kinase …

[HTML][HTML] T790M and acquired resistance of EGFR TKI: a literature review of clinical reports

C Ma, S Wei, Y Song - Journal of thoracic disease, 2011 - ncbi.nlm.nih.gov
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) such as gefitinib
and erlotinib are promising therapies for patients with advanced non-small-cell lung cancer …

Managing treatment-related adverse events associated with EGFR tyrosine kinase inhibitors in advanced non-small-cell lung cancer

V Hirsh - Current Oncology, 2011 - mdpi.com
Non-small-cell lung cancer (nsclc) has the highest prevalence of all types of lung cancer,
which is the second most common cancer and the leading cause of cancer-related mortality …

Effects of Erlotinib in EGFR Mutated Non-Small Cell Lung Cancers with Resistance to Gefitinib

DB Costa, KSH Nguyen, BC Cho, LV Sequist… - Clinical cancer …, 2008 - AACR
Purpose: Most lung cancers with activating epidermal growth factor receptor (EGFR)
mutations respond to gefitinib; however, resistance to this tyrosine kinase inhibitor (TKI) …

[HTML][HTML] Efficacy of erlotinib for brain and leptomeningeal metastases in patients with lung adenocarcinoma who showed initial good response to gefitinib

T Katayama, J Shimizu, K Suda, R Onozato… - Journal of Thoracic …, 2009 - Elsevier
Introduction The efficacy of high-dose (1250 mg/d) gefitinib for the treatment of
leptomeningeal metastasis in a patient with lung cancer harboring a mutation in the …

EGFR-mutated oncogene-addicted non-small cell lung cancer: current trends and future prospects

JC Soria, TS Mok, F Cappuzzo, PA Jänne - Cancer treatment reviews, 2012 - Elsevier
Non-small cell lung cancer (NSCLC) tumours with certain mutations in the epidermal growth
factor receptor (EGFR) tyrosine kinase have been termed 'oncogene addicted'to reflect their …

[HTML][HTML] Contrast-enhanced T1-weighted image radiomics of brain metastases may predict EGFR mutation status in primary lung cancer

SJ Ahn, H Kwon, JJ Yang, M Park, YJ Cha, SH Suh… - Scientific reports, 2020 - nature.com
Identification of EGFR mutations is critical to the treatment of primary lung cancer and brain
metastases (BMs). Here, we explored whether radiomic features of contrast-enhanced T1 …

Management of diarrhea induced by epidermal growth factor receptor tyrosine kinase inhibitors

V Hirsh, N Blais, R Burkes, S Verma, K Croitoru - Current oncology, 2014 - mdpi.com
Abstract Treatment for non-small-cell lung cancer (nsclc) is moving away from traditional
chemotherapy toward personalized medicine. The reversible tyrosine kinase inhibitors (tkis) …