Ligands for the nuclear receptor superfamily control many aspects of biology, including
development, reproduction, and homeostasis, through regulation of the transcriptional …

In addition to its role as a sex hormone, oestrogen affects the structure and function of the
nervous system. Oestrogen receptors are expressed in brain regions that are involved in sex …

Breast cancer is a heterogeneous disease affecting thousands of people every year.
Multiple factors are responsible in causing breast cancer while a number of treatment …

We assessed the preclinical characteristics of a novel, stringently screened selective
estrogen receptor modulator, bazedoxifene acetate, including its ability to bind to and …

The nuclear receptor heterodimers of liver X receptor (LXR) and retinoid X receptor (RXR)
are key transcriptional regulators of genes involved in lipid homeostasis and inflammation …

Tamoxifen is effective for the prevention and treatment of estrogen-dependent breast
cancers, but is associated with an increased incidence of endometrial tumors. We report the …

The nuclear receptor family comprises ligand-dependent and orphan receptors. To the latter
group belong the estrogen receptor-related receptors (ERRs) for which conflicting results …

The breast cancer suppressor protein, BRCA1, is a ubiquitin ligase expressed in a wide
range of tissues. However, inheritance of a single BRCA1 mutation significantly increases a …

Substantial evidence now exists that intrinsic free-radical scavenging contributes to the
receptor-independent neuroprotective effects of estrogens. This activity is inherently …

Gliomas are the most common type of primary malignant brain tumor and have a very poor
prognosis. Little is known, however, about the etiology of these tumors. Evidence from a …