The peptides of the tachykinin family are widely distributed within the mammalian peripheral
and central nervous systems and play a well-recognized role as excitatory …

Mast cells are critical players in allergic reactions, but they have also been shown to be
important in immunity and recently also in inflammatory diseases, especially asthma …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

In addition to the classical neurotransmitters, acetylcholine and noradrenaline, a wide
number of peptides with neurotransmitter activity have been identified in the past few years …

Abstract Purpose of Review Atopic dermatitis (AD) and allergic asthma are complex
disorders with significant public health burden. This review provides an overview of the …

Many data suggest the deep involvement of the substance P (SP)/neurokinin (NK)-1
receptor system in cancer:(1) Tumor cells express SP, NK-1 receptors and mRNA for the …

In addition to the well-known function of ACTH as the main regulator of adrenal
steroidogenesis, we have previously demonstrated its effect on the transcriptional …

We have developed an automated SELEX (Systematic Evolution of Ligands by EXponential
Enrichment) process that allows the execution of in vitro selection cycles without any direct …

Hemokinin-1 (HK-1) is a novel substance P (SP)-like peptide that is encoded by the
preprotachykinin C (PPT-C) gene recently identified in mouse B cells and shown to be a …

We report four human tachykinins, endokinins A, B, C, and D (EKA–D), encoded from a
single tachykinin precursor 4 gene that generates four mRNAs (α, β, γ, and δ). Tachykinin 4 …