The tumor suppressor protein p53 induces or represses the expression of a variety of target
genes involved in cell cycle control, senescence, and apoptosis in response to oncogenic or …

Papillary and invasive cancers of the urinary bladder appear to evolve and progress through
distinct molecular pathways. Invasion in bladder cancer forebodes a graver prognosis, and …

MicroRNAs regulate gene expression by repressing translation or directing sequence-
specific degradation of their complementary mRNA. We recently reported that miR-203 is …

Mutations in the tumor suppressor p53 are detectable in over 50% of all human
malignancies. Mutant p53 protein is incapable of transactivating its downstream target …

The tumor suppressor p53 plays a crucial role in the cellular response to DNA damage by
transcriptional activation of numerous downstream genes. Although a considerable number …

Two genomes, nuclear and mitochondrial, exist in humans although information contained
in the mitochondrial genome has not been fully utilized in cancer epidemiology. Over the last …

Cancer predisposition, onset and therapeutic response can be critically determined by the
integrity of the tumor suppressor p53. The majority of human cancers appear to exhibit either …

Bridge splitting reactions between [Pd (C 2, N-dmba)(μ-X)] 2 (dmba= N, N-
dimethylbenzylamine; X= Cl, I, N 3, NCO) and 2, 6-lutidine (lut) in the 1: 2 molar ratio at room …

Cleavage reactions involving the halide-bridged [Pd (μ-Cl)(C 2, N-aphox)] 2 precursor
(aphox= acetophenone oxime) with thioamides, in the 1: 2 molar ratio, yielded mononuclear …

1. ABSTRACT p53 is the primary arbiter of the mammalian cell's response to stress, the
governor of life and death. It is the nexus upon which signals converge from an array of …