[HTML][HTML] Natural products for drug discovery in the 21st century: innovations for novel drug discovery
NE Thomford, DA Senthebane, A Rowe… - International journal of …, 2018 - mdpi.com
The therapeutic properties of plants have been recognised since time immemorial. Many
pathological conditions have been treated using plant-derived medicines. These medicines …
pathological conditions have been treated using plant-derived medicines. These medicines …
[HTML][HTML] Epigenome-wide association studies: current knowledge, strategies and recommendations
The aetiology and pathophysiology of complex diseases are driven by the interaction
between genetic and environmental factors. The variability in risk and outcomes in these …
between genetic and environmental factors. The variability in risk and outcomes in these …
[HTML][HTML] Multiomic profiling of checkpoint inhibitor-treated melanoma: Identifying predictors of response and resistance, and markers of biological discordance
F Newell, IP da Silva, PA Johansson, AM Menzies… - Cancer cell, 2022 - cell.com
We concurrently examine the whole genome, transcriptome, methylome, and immune cell
infiltrates in baseline tumors from 77 patients with advanced cutaneous melanoma treated …
infiltrates in baseline tumors from 77 patients with advanced cutaneous melanoma treated …
[HTML][HTML] Genetic drivers of epigenetic and transcriptional variation in human immune cells
Characterizing the multifaceted contribution of genetic and epigenetic factors to disease
phenotypes is a major challenge in human genetics and medicine. We carried out high …
phenotypes is a major challenge in human genetics and medicine. We carried out high …
The genetic basis and cell of origin of mixed phenotype acute leukaemia
TB Alexander, Z Gu, I Iacobucci, K Dickerson, JK Choi… - Nature, 2018 - nature.com
Mixed phenotype acute leukaemia (MPAL) is a high-risk subtype of leukaemia with myeloid
and lymphoid features, limited genetic characterization, and a lack of consensus regarding …
and lymphoid features, limited genetic characterization, and a lack of consensus regarding …
Comprehensive analysis of DNA methylation data with RnBeads
RnBeads is a software tool for large-scale analysis and interpretation of DNA methylation
data, providing a user-friendly analysis workflow that yields detailed hypertext reports …
data, providing a user-friendly analysis workflow that yields detailed hypertext reports …
[HTML][HTML] The role of natural products as sources of therapeutic agents for innovative drug discovery
K Dzobo - Comprehensive pharmacology, 2022 - ncbi.nlm.nih.gov
Emerging threats to human health require a concerted effort in search of both preventive and
treatment strategies, placing natural products at the center of efforts to obtain new therapies …
treatment strategies, placing natural products at the center of efforts to obtain new therapies …
[HTML][HTML] TET2 mutations are associated with hypermethylation at key regulatory enhancers in normal and malignant hematopoiesis
Mutations in the epigenetic modifier TET2 are frequent in myeloid malignancies and clonal
hematopoiesis of indeterminate potential (CHIP) and clonal cytopenia of undetermined …
hematopoiesis of indeterminate potential (CHIP) and clonal cytopenia of undetermined …
[HTML][HTML] Immunogenomic landscape of hematological malignancies
Understanding factors that shape the immune landscape across hematological
malignancies is essential for immunotherapy development. We integrated over 8,000 …
malignancies is essential for immunotherapy development. We integrated over 8,000 …
Comparative genomics provides etiologic and biological insight into melanoma subtypes
Melanoma is a cancer of melanocytes, with multiple subtypes based on body site location.
Cutaneous melanoma is associated with skin exposed to ultraviolet radiation; uveal …
Cutaneous melanoma is associated with skin exposed to ultraviolet radiation; uveal …