Left ventricular remodeling after myocardial infarction: pathophysiology and therapy

MGSJ Sutton, N Sharpe - Circulation, 2000 - Am Heart Assoc
renin-angiotensin-aldosterone system, and stimulates the production of atrial and brain
natriuretic peptides (ANP and BNP). 10 Augmented shortening and increased heart rate …

Tissue renin-angiotensin-aldosterone systems: Targets for pharmacological therapy

M Bader - Annual review of pharmacology and toxicology, 2010 - annualreviews.org
The renin-angiotensin-aldosterone system is one of the most important systems in
cardiovascular control and in the pathogenesis of cardiovascular diseases. Therefore, it is …

Progressive left ventricular dysfunction and remodeling after myocardial infarction. Potential mechanisms and early predictors.

P Gaudron, C Eilles, I Kugler, G Ertl - Circulation, 1993 - Am Heart Assoc
BACKGROUND Left ventricular enlargement and the development of chronic heart failure
are potent predictors of survival in patients after myocardial infarction. Prospective studies …

Effects of the angiotensin converting enzyme inhibitor enalapril on the long-term progression of left ventricular dysfunction in patients with heart failure. SOLVD …

MA Konstam, MF Rousseau, MW Kronenberg… - Circulation, 1992 - Am Heart Assoc
BACKGROUND In patients with heart failure, activation of the renin-angiotensin system is
common and has been postulated to provide a stimulus for further left ventricular (LV) …

Heart failure: the frequent, forgotten, and often fatal complication of diabetes

DSH Bell - Diabetes care, 2003 - Am Diabetes Assoc
There is a high frequency of heart failure (HF) accompanied by an increased mortality risk
for patients with diabetes. The poor prognosis of these patients has been explained by an …

The effect of the angiotensin-converting–enzyme inhibitor zofenopril on mortality and morbidity after anterior myocardial infarction

E Ambrosioni, C Borghi, B Magnani - New England Journal of …, 1995 - Mass Medical Soc
Background Left ventricular dilatation and neuroendocrine activation are common after
acute anterior myocardial infarction. Long-term treatment with an angiotensin-converting …

[HTML][HTML] Effects of the early administration of enalapril on mortality in patients with acute myocardial infarction: results of the Cooperative New Scandinavian Enalapril …

K Swedberg, P Held, J Kjekshus… - … England Journal of …, 1992 - Mass Medical Soc
Background. Long-term administration of angiotensin-converting—enzyme (ACE) inhibitors
has been shown to improve survival in patients with symptomatic left ventricular failure and …

Navigating the crossroads of coronary artery disease and heart failure

M Gheorghiade, G Sopko, L De Luca, EJ Velazquez… - Circulation, 2006 - Am Heart Assoc
Among patients with HF or evidence of LV dysfunction after acute MI enrolled in the Optimal
Trial in Myocardial Infarction With the Angiotensin II Antagonist Losartan (OPTIMAAL) …

Cardiovascular death and left ventricular remodeling two years after myocardial infarction: baseline predictors and impact of long-term use of captopril: information …

MSJ Sutton, MA Pfeffer, L Moye, T Plappert… - Circulation, 1997 - Am Heart Assoc
Background We quantified cardiovascular death and/or left ventricular (LV) dilatation in
patients from the SAVE trial to determine whether dilatation continued beyond 1 year …

Reverse remodeling in heart failure—mechanisms and therapeutic opportunities

N Koitabashi, DA Kass - Nature Reviews Cardiology, 2012 - nature.com
Heart failure (HF) involves changes in cardiac structure, myocardial composition, myocyte
deformation, and multiple biochemical and molecular alterations that impact heart function …