Aspirin is integral to the secondary prevention of cardiovascular disease and acts to impair
the development of platelet-mediated atherothromboembolic events by irreversible inhibition …

Platelet (PLT) production represents the final stage of megakaryocyte (MK) development.
During differentiation, bone marrow MKs extend and release long, branched proPLTs into …

Cyclooxygenase (COX)-1 or-2 and prostaglandin (PG) synthases catalyze the formation of
various PGs and thromboxane (TX) A2. We have investigated the expression and activity of …

P-selectin is an adhesion receptor for leukocytes expressed by activated platelets and
endothelial cells. To assess a possible role of P-selectin in platelet clearance, we adapted …

BACKGROUND: Although it is usually involved only in nucleated cells (NCs), artificially
enucleated cells also lose viability by a programmed process of cell death called apoptosis …

BACKGROUND: The quality of platelet concentrates (PCs) is primarily determined in vitro by
selective methods (eg, pH, aggregometry), which provide only limited information on certain …

Electroconvulsive therapy (ECT) is a well-established, safe and effective treatment in
severest or drug-resistant affective disorders. The potential relation between any peripheral …

The mechanism of ADP-mediated platelet activation has been difficult to unravel due to the
large number of receptors for extracellular nucleotides (P2 receptors). mRNA levels in …

The reticulated platelet count relies upon the assumption that newly formed platelets contain
a residual amount of RNA which selectively binds the dye thiazole orange (TO) and greatly …

Brain-derived neurotrophic factor (BDNF) is a protein often studied in psychiatric
populations. Commercial ELISA kits have been validated for measuring BDNF in blood …