As an essential micronutrient, manganese (Mn) participates in various physiological
processes and plays important roles in host immune system, hematopoiesis, endocrine …

Nano‐immunotherapy has been recognized as a highly promising strategy for cancer
treatment in recent decades, which combines nanotechnology and immunotherapy to …

As a promising cancer treatment, photodynamic therapy (PDT) still achieved limited clinical
success due to the severe hypoxia and programmed death ligand-1 (PD-L1) over-expressed …

Currently, the role of the lysosome, endoplasmic reticulum, or dictyosome in the transcription
and translation of programmed cell death ligand 1 (PD‐L1) is well revealed, but the role and …

At present, radiotherapy (RT) still acquires limited success in clinical due to the lessened
DNA damage under hypoxia and acquired immune tolerance owing to the amplified …

Recently, it was newly revealed that the DNA damage induced by cis‑platinum (Cis-Pt)
mediated chemotherapy was significantly impaired by the highly expressed programmed …

Immunotherapy has achieved great success recently and opened a new avenue for anti-
tumor treatment. Programmed cell death 1/programmed cell death ligand 1 (PD-1/PD-L1) …

Currently, immune checkpoint blockade (ICB) therapies that target the programmed cell
death ligand-1 (PD-L1) have been used as revolutionary cancer treatments in the clinic …

Nowadays, photodynamic therapy (PDT) has become a novel effect modality for cancer
therapy. But, facing the extremely hypoxic tumor microenvironment, the efficacy of PDT is still …

At present, the tumor's poor oxygen perfusion and limited tumor drug permeation are the
major bottlenecks that limit the therapeutic effectiveness of the oxygen-sensitive antitumor …