Cardiac hypertrophy is commonly observed in conditions of increased hemodynamic or
metabolic stress. This hypertrophy is not compensatory but rather reflects activation of …

The third generation β-blockers possess important ancillary properties besides inhibiting β-
adrenoceptors. Among them, nebivolol activates nitric oxide synthase (NOS). Nebivolol and …

A myocardial bridge is a segment of a coronary artery that travels into the myocardium
instead of the normal epicardial course. Although it is general perception that myocardial …

Background The fixed-dose combination of any two antihypertensive drugs from different
drug classes is typically more effective in reducing blood pressure than a dose increase of …

Abstract Objective Left anterior descending Myocardial Bridge (LADMB) is considered a
benign condition and actually becomes a forgotten cause of serious cardiac events. This …

The management of arterial hypertension is very challenging in everyday clinical practice.
Blood pressure control rates remain disappointingly low, despite intense efforts. Poor …

Nebivolol, unlike other selective β1-receptor blockers, induces vasodilation attributable to
increased NO bioavailability. The relative contribution of this mechanism to the blood …

Primary neurodegenerative autonomic disorders are characterized clinically by loss of
autonomic regulation of blood pressure. The clinical picture is dominated by orthostatic …

Nebivolol is a β1-adrenergic blocker that also elicits renal vasodilation and increases the
glomerular filtration rate (GFR). However, its direct actions on the renal microvasculature …

Age-associated diseases represent a growing burden for global health systems in our aging
society. Consequently, we urgently need innovative strategies to counteract these …