Availability of artificial light and light-emitting devices have altered human temporal life,
allowing 24-hour healthcare, commerce and production, and expanding social life around …

Chronic insomnia disorder, which affects 6–10% of the population, is diagnostically
characterized by ongoing difficulties with initiating or maintaining sleep occurring at least …

As opioid-related fatalities continue to rise, the need for novel opioid use disorder (OUD)
treatments could not be more urgent. Two separate hypothalamic neuropeptide systems …

The midline and intralaminar nuclei of the thalamus form a major part of the “limbic
thalamus;” that is, thalamic structures anatomically and functionally linked with the limbic …

Palatable taste can stimulate appetite in the absence of hunger, and individual differences in
hedonic eating may be critical to overeating. Women are more prone to obesity and binge …

The roles of the hypothalamus and particularly the lateral hypothalamus (LH) in the
regulation of inflammation and pain have been widely studied. The LH consists of a …

The initiation of alcohol use early in life is one of the strongest predictors of developing a
future alcohol use disorder. Clinical studies have identified specific behaviors during early …

Peptides promote the mitogenesis and migration of tumor cells, and cancer cells
overexpress peptide receptors. The involvement of the orexinergic system in cancer is …

At its discovery, orexin/hypocretin (OX) was hypothesized to promote food intake.
Subsequently, with the identification of the participation of OX in numerous other …

Rationale. Current evidence and literature reviews provide a strong justification for
examining the orexin receptor (OXR) system as a therapeutic target in substance use …