[HTML][HTML] Machine learning models to predict ligand binding affinity for the orexin 1 receptor
VY Zhang, SL O'Connor, WJ Welsh… - Artificial Intelligence …, 2024 - Elsevier
The orexin 1 receptor (OX1R) is a G-protein coupled receptor that regulates a variety of
physiological processes through interactions with the neuropeptides orexin A and B …
physiological processes through interactions with the neuropeptides orexin A and B …
An anatomically distinct subpopulation of orexin neurons project from the lateral hypothalamus to the olfactory bulb
M Qi, DA Fadool, DA Storace - Journal of Comparative …, 2023 - Wiley Online Library
Olfactory cues play a key role in natural behaviors such as finding food, finding mates, and
avoiding predators. In principle, the ability of the olfactory system to carry out these …
avoiding predators. In principle, the ability of the olfactory system to carry out these …
Use of drug purchase tasks in medications development research: orexin system regulation of cocaine and drug demand
JC Strickland, KW Hatton, LR Hays… - Behavioural …, 2023 - journals.lww.com
Commodity purchase tasks provide a useful method for evaluating behavioral economic
demand in the human laboratory. Recent research has shown how responding to purchase …
demand in the human laboratory. Recent research has shown how responding to purchase …
[HTML][HTML] Involvement of the orexinergic system in feeding
P Marcos, R Coveñas - Applied Sciences, 2021 - mdpi.com
To know the processes involved in feeding, the dysregulation of hypothalamic
neuropeptides promoting anorexigenic/orexigenic mechanisms must be investigated. Many …
neuropeptides promoting anorexigenic/orexigenic mechanisms must be investigated. Many …
The potential use of daridorexant in eating disorders: beyond the treatment of insomnia?
A Caldiroli, LM Affaticati, E Capuzzi… - International Clinical …, 2024 - journals.lww.com
A strong interplay exists between sleep and dietary habits, and sleep disturbances have
been repeatedly documented in individuals with eating disorders (EDs). The orexin system …
been repeatedly documented in individuals with eating disorders (EDs). The orexin system …
Effects of intracerebroventricular leptin and orexin‐A on the baroreflex control of renal sympathetic nerve activity in conscious rats fed a normal or high‐fat diet
C Huang, S AlMarabeh, J Cavers… - Clinical and …, 2021 - Wiley Online Library
This study examined the effect of leptin and orexin‐A on autonomic baroreflex control in
conscious Wistar rats exposed to high‐fat (45% fat) or normal (3.4%) diet for 4 weeks. Renal …
conscious Wistar rats exposed to high‐fat (45% fat) or normal (3.4%) diet for 4 weeks. Renal …
[HTML][HTML] Daridorexant, a Recently Approved Dual Orexin Receptor Antagonists (DORA) in Treatment of Insomnia
DS Chakraborty, S Choudhury, S Lahiry - Sleep Science, 2023 - thieme-connect.com
Insomnia is one of the major challenges in medical science nowadays as it leads to great
socio-economic burden by impairing daytime function as well as the development of …
socio-economic burden by impairing daytime function as well as the development of …
[HTML][HTML] Subpopulations of hypocretin/orexin neurons differ in measures of their cell proliferation, dynorphin co-expression, projections, and response to embryonic …
N Yasmin, AD Collier, O Karatayev, AR Abdulai… - Scientific Reports, 2023 - nature.com
Numerous studies in animals demonstrate that embryonic exposure to ethanol (EtOH) at low-
moderate doses stimulates neurogenesis and increases the number of hypothalamic …
moderate doses stimulates neurogenesis and increases the number of hypothalamic …
Adolescent alcohol exposure increases orexin-A/hypocretin-1 in the anterior hypothalamus
Adolescence is a time of marked changes in sleep, neuromaturation, and alcohol use. While
there is substantial evidence that alcohol disrupts sleep and that disrupted sleep may play a …
there is substantial evidence that alcohol disrupts sleep and that disrupted sleep may play a …
[HTML][HTML] Habitual behaviour associated with exposure to high-calorie diet is prevented by an orexin-receptor-1 antagonist
S Merlin, TM Furlong - Addiction neuroscience, 2022 - Elsevier
Habitual actions, which are associated with addictive behaviours, contribute to the loss of
control of food seeking seen following exposure to calorie-dense foods in rats. Antagonism …
control of food seeking seen following exposure to calorie-dense foods in rats. Antagonism …