Burden, pathology, and costs of malaria in pregnancy: new developments for an old problem

SJ Rogerson, M Desai, A Mayor, E Sicuri… - The Lancet infectious …, 2018 - thelancet.com
Over the past 10 years, knowledge of the burden, economic costs, and consequences of
malaria in pregnancy has improved, and the prevalence of malaria caused by Plasmodium …

First-in-human, randomized, double-blind clinical trial of differentially adjuvanted PAMVAC, a vaccine candidate to prevent pregnancy-associated malaria

B Mordmüller, M Sulyok, D Egger-Adam… - Clinical Infectious …, 2019 - academic.oup.com
Background Malaria in pregnancy has major impacts on mother and child health. To
complement existing interventions, such as intermittent preventive treatment and use of …

A conformational epitope in placental malaria vaccine antigen VAR2CSA: What does it teach us?

JYA Doritchamou, JP Renn, L Hviid, PE Duffy - PLoS Pathogens, 2023 - journals.plos.org
VAR2CSA is the Plasmodium falciparum variant surface antigen that mediates binding of
infected erythrocytes to chondroitin sulfate A (CSA) and their sequestration in intervillous …

Allelic variants of full-length VAR2CSA, the placental malaria vaccine candidate, differ in antigenicity and receptor binding affinity

JP Renn, JYA Doritchamou, BCN Tentokam… - Communications …, 2021 - nature.com
Plasmodium falciparum-infected erythrocytes (IE) sequester in the placenta via surface
protein VAR2CSA, which binds chondroitin sulfate A (CSA) expressed on the …

Increased risk of low birth weight in women with placental malaria associated with P. falciparum VAR2CSA clade

JC Patel, NJ Hathaway, CM Parobek, KL Thwai… - Scientific reports, 2017 - nature.com
Pregnancy associated malaria (PAM) causes adverse pregnancy and birth outcomes owing
to Plasmodium falciparum accumulation in the placenta. Placental accumulation is mediated …

Cryo-EM reveals the conformational epitope of human monoclonal antibody PAM1. 4 broadly reacting with polymorphic malarial protein VAR2CSA

SSR Raghavan, R Dagil, M Lopez-Perez… - PLoS …, 2022 - journals.plos.org
Malaria during pregnancy is a major global health problem caused by infection with
Plasmodium falciparum parasites. Severe effects arise from the accumulation of infected …

VAR2CSA-Mediated Host Defense Evasion of Plasmodium falciparum Infected Erythrocytes in Placental Malaria

A Tomlinson, JP Semblat, B Gamain… - Frontiers in …, 2021 - frontiersin.org
Over 30 million women living in P. falciparum endemic areas are at risk of developing
malaria during pregnancy every year. Placental malaria is characterized by massive …

Pre-clinical and clinical development of the first placental malaria vaccine

C Pehrson, A Salanti, TG Theander… - Expert Review of …, 2017 - Taylor & Francis
Introduction: Malaria during pregnancy is a massive health problem in endemic areas.
Placental malaria infections caused by Plasmodium falciparum are responsible for up to one …

Progress and new horizons toward a VAR2CSA-based placental malaria vaccine

JYA Doritchamou, J Suurbaar… - Expert Review of …, 2021 - Taylor & Francis
Introduction: Several malaria vaccines are under various phases of development with some
promising results. In placental malaria (PM) a deliberately anti-disease approach is …

Molecular principles of intrauterine growth restriction in Plasmodium falciparum infection

J Seitz, DM Morales-Prieto, RR Favaro… - Frontiers in …, 2019 - frontiersin.org
Malaria in pregnancy still constitutes a particular medical challenge in tropical and
subtropical regions. Of the five Plasmodium species that are pathogenic to humans, infection …