Burden, pathology, and costs of malaria in pregnancy: new developments for an old problem
Over the past 10 years, knowledge of the burden, economic costs, and consequences of
malaria in pregnancy has improved, and the prevalence of malaria caused by Plasmodium …
malaria in pregnancy has improved, and the prevalence of malaria caused by Plasmodium …
First-in-human, randomized, double-blind clinical trial of differentially adjuvanted PAMVAC, a vaccine candidate to prevent pregnancy-associated malaria
B Mordmüller, M Sulyok, D Egger-Adam… - Clinical Infectious …, 2019 - academic.oup.com
Background Malaria in pregnancy has major impacts on mother and child health. To
complement existing interventions, such as intermittent preventive treatment and use of …
complement existing interventions, such as intermittent preventive treatment and use of …
A conformational epitope in placental malaria vaccine antigen VAR2CSA: What does it teach us?
JYA Doritchamou, JP Renn, L Hviid, PE Duffy - PLoS Pathogens, 2023 - journals.plos.org
VAR2CSA is the Plasmodium falciparum variant surface antigen that mediates binding of
infected erythrocytes to chondroitin sulfate A (CSA) and their sequestration in intervillous …
infected erythrocytes to chondroitin sulfate A (CSA) and their sequestration in intervillous …
Allelic variants of full-length VAR2CSA, the placental malaria vaccine candidate, differ in antigenicity and receptor binding affinity
JP Renn, JYA Doritchamou, BCN Tentokam… - Communications …, 2021 - nature.com
Plasmodium falciparum-infected erythrocytes (IE) sequester in the placenta via surface
protein VAR2CSA, which binds chondroitin sulfate A (CSA) expressed on the …
protein VAR2CSA, which binds chondroitin sulfate A (CSA) expressed on the …
Increased risk of low birth weight in women with placental malaria associated with P. falciparum VAR2CSA clade
Pregnancy associated malaria (PAM) causes adverse pregnancy and birth outcomes owing
to Plasmodium falciparum accumulation in the placenta. Placental accumulation is mediated …
to Plasmodium falciparum accumulation in the placenta. Placental accumulation is mediated …
Cryo-EM reveals the conformational epitope of human monoclonal antibody PAM1. 4 broadly reacting with polymorphic malarial protein VAR2CSA
Malaria during pregnancy is a major global health problem caused by infection with
Plasmodium falciparum parasites. Severe effects arise from the accumulation of infected …
Plasmodium falciparum parasites. Severe effects arise from the accumulation of infected …
VAR2CSA-Mediated Host Defense Evasion of Plasmodium falciparum Infected Erythrocytes in Placental Malaria
A Tomlinson, JP Semblat, B Gamain… - Frontiers in …, 2021 - frontiersin.org
Over 30 million women living in P. falciparum endemic areas are at risk of developing
malaria during pregnancy every year. Placental malaria is characterized by massive …
malaria during pregnancy every year. Placental malaria is characterized by massive …
Pre-clinical and clinical development of the first placental malaria vaccine
C Pehrson, A Salanti, TG Theander… - Expert Review of …, 2017 - Taylor & Francis
Introduction: Malaria during pregnancy is a massive health problem in endemic areas.
Placental malaria infections caused by Plasmodium falciparum are responsible for up to one …
Placental malaria infections caused by Plasmodium falciparum are responsible for up to one …
Progress and new horizons toward a VAR2CSA-based placental malaria vaccine
JYA Doritchamou, J Suurbaar… - Expert Review of …, 2021 - Taylor & Francis
Introduction: Several malaria vaccines are under various phases of development with some
promising results. In placental malaria (PM) a deliberately anti-disease approach is …
promising results. In placental malaria (PM) a deliberately anti-disease approach is …
Molecular principles of intrauterine growth restriction in Plasmodium falciparum infection
J Seitz, DM Morales-Prieto, RR Favaro… - Frontiers in …, 2019 - frontiersin.org
Malaria in pregnancy still constitutes a particular medical challenge in tropical and
subtropical regions. Of the five Plasmodium species that are pathogenic to humans, infection …
subtropical regions. Of the five Plasmodium species that are pathogenic to humans, infection …