Copper toxicity is a critical issue in the development of copper-based catalysts for copper (I)-
catalyzed azide–alkyne cycloaddition (CuAAC) reactions for applications in living systems …

Ferroptosis is a form of regulated cell necrosis, as a consequence of Fe (II)-dependent lipid
peroxidation. Although ferroptosis has been linked to cancer cell death, neurodegeneration …

Myoferlin, an emerging oncoprotein, has been associated with a low survival in several
cancer types including pancreas ductal adenocarcinoma where it controls mitochondria …

Iron and its homeostasis are intimately tied to the inflammatory response. The adaptation to
iron deficiency, which confers resistance to infection and improves the inflammatory …

Endometriosis, characterized by the presence of extra-uterine endometrium, is a common
gynecologic disorder in reproductive-age women. Although the detailed molecular …

Colorectal cancer (CRC) is the third leading cause of cancer deaths worldwide and is
characterised by frequently mutated genes, such as APC, TP53, KRAS and BRAF. The …

Zinc is an essential trace element playing fundamental roles in cellular metabolism. It acts
mostly by binding a wide range of proteins, thus affecting a broad spectrum of biological …

Occupational and environmental exposures to metals are closely associated with an
increased risk of various cancers. Although carcinogenesis caused by metals has been …

The chemical and biological effects of thiosemicarbazones have received considerable
interest from medicinal chemists for many years. This is attributed to, first, their wide …

Hypoxia and acidity provide microenvironment for selection under evolutionary pressure
and proliferation in cancer cells. Carbonic anhydrases (CAs) are a superfamily of …