It is particularly challenging to develop a truly effective pharmacotherapy for cocaine use
disorder (CUD) treatment. Accelerating cocaine metabolism via hydrolysis at cocaine …

Cocaine is a widely abused, hepatotoxic drug without an FDA-approved pharmacotherapy
specific for cocaine addiction or overdose. It is recognized as a promising therapeutic …

As well known, cocaine induces stimulant effects and dopamine transporter (DAT) trafficking
to the plasma membrane of dopaminergic neurons. In the present study, we examined …

A combined computational and experimental study has been carried out to explore and test
a quantitative correlation relationship between the relative catalytic efficiency (RCE) of …

It is recognized as a promising therapeutic strategy for cocaine use disorder to develop an
efficient enzyme which can rapidly convert cocaine to physiologically inactive metabolites …

Cocaine dependence is a serious world-wide public health problem without an FDA-
approved pharmacotherapy. We recently designed and discovered a highly efficient long …

In the presence of alcohol, cocaine metabolism produces a number of metabolites, including
three toxic ones (cocaethylene, norcocaine, and norcocaethylene) which are all more toxic …

Актуальность. Хирургическое лечение повреждений лодыжечного сегмента
осуществляется в соответствии с принципами лечения внутрисуставных переломов …