The canonical Wnt–β-catenin pathway is a complex, evolutionarily conserved signalling
mechanism that regulates fundamental physiological and pathological processes. Wnt–β …

β-catenin (encoded by CTNNB1) is a subunit of the cell surface cadherin protein complex
that acts as an intracellular signal transducer in the WNT signaling pathway; alterations in its …

Fibrosis is the final hallmark of pathological remodeling, which is a major contributor to the
pathogenesis of various chronic diseases and aging-related organ failure to fully control …

WNT-5A plays critical roles in a myriad of processes from embryonic morphogenesis to the
maintenance of post-natal homeostasis. WNT-5A knock-out mice fail to survive and present …

Liver fibrosis is a common wound-healing response to chronic liver injuries, including
alcoholic or drug toxicity, persistent viral infection, and genetic factors. Myofibroblastic …

Cholestatic liver diseases including primary biliary cholangitis (PBC) and primary sclerosing
cholangitis (PSC) are associated with active hepatic fibrogenesis, which can ultimately lead …

Background Hepatic fibrosis is caused by chronic liver injury and may progress toward liver
cirrhosis, and even hepatocellular carcinoma. However, current treatment is not satisfactory …

Development of an effective treatment against advanced tumors remains a major challenge
for cancer immunotherapy. Approximately 50% of human melanoma is driven by B-Raf proto …

The liver is a complex organ that requires multiple rounds of cell fate decision for
development and homeostasis throughout the lifetime. During the earliest phases of …

Liver fibrosis is an essential component of chronic liver disease (CLD) and
hepatocarcinogenesis. The fibrotic stroma is a consequence of sustained liver damage …