Lipopolysaccharide molecules represent a unique family of glycolipids based on a highly
conserved lipid moiety known as lipid A. These molecules are produced by most gram …

The brain is well protected against microbial invasion by cellular barriers, such as the blood-
brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCSFB). In addition, cells …

Bacterial genomes are remarkably stable from one generation to the next but are plastic on
an evolutionary time scale, substantially shaped by horizontal gene transfer, genome …

Respiratory tract infections are an important cause of morbidity and mortality worldwide.
Chief among these are infections involving the lower airways. The opportunistic bacterial …

The post-translational modification (PTM) of proteins plays a critical role in the regulation of
a broad range of cellular processes in eukaryotes. Yet their role in governing similar systems …

This review is aimed at readers seeking an introductory overview, teaching courses and
interested in visionary ideas. It first describes the range of topics covered by evolutionary …

Nontypeable Haemophilus influenzae (NTH i) is a commensal microbe often isolated from
the upper and lower respiratory tract. This bacterial species can cause sinusitis, acute otitis …

The mucosal immune system prevents microorganism invasion through mucosal surfaces
and consists of inductive and effector sites. Nasopharynx-associated lymphoid tissue (NALT) …

ABSTRACT COPD is a seriously disabling respiratory condition that inexorably progresses
to disability and mortality. It affects approximately 10% of the population globally with a …

We demonstrated previously that phosphocholine and phosphocholine-modified
macromolecules efficiently inhibit ATP-dependent release of interleukin-1β from human and …