Endoplasmic reticulum stress signalling and the pathogenesis of non-alcoholic fatty liver disease
The global epidemic of obesity has been accompanied by a rising burden of non-alcoholic
fatty liver disease (NAFLD), with manifestations ranging from simple steatosis to non …
fatty liver disease (NAFLD), with manifestations ranging from simple steatosis to non …
The integrated stress response
In response to diverse stress stimuli, eukaryotic cells activate a common adaptive pathway,
termed the integrated stress response (ISR), to restore cellular homeostasis. The core event …
termed the integrated stress response (ISR), to restore cellular homeostasis. The core event …
The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression
W B'chir, AC Maurin, V Carraro, J Averous… - Nucleic acids …, 2013 - academic.oup.com
In response to different environmental stresses, eIF2α phosphorylation represses global
translation coincident with preferential translation of ATF4, a master regulator controlling the …
translation coincident with preferential translation of ATF4, a master regulator controlling the …
Nutrient sensing and TOR signaling in yeast and mammals
A González, MN Hall - The EMBO journal, 2017 - embopress.org
Coordinating cell growth with nutrient availability is critical for cell survival. The evolutionarily
conserved TOR (target of rapamycin) controls cell growth in response to nutrients, in …
conserved TOR (target of rapamycin) controls cell growth in response to nutrients, in …
[HTML][HTML] Axonally synthesized ATF4 transmits a neurodegenerative signal across brain regions
In Alzheimer's disease (AD) brain, exposure of axons to Aβ causes pathogenic changes that
spread retrogradely by unknown mechanisms, affecting the entire neuron. We found that …
spread retrogradely by unknown mechanisms, affecting the entire neuron. We found that …
Arginase: an emerging key player in the mammalian immune system
M Munder - British journal of pharmacology, 2009 - Wiley Online Library
The enzyme arginase metabolizes L‐arginine to L‐ornithine and urea. Besides its
fundamental role in the hepatic urea cycle, arginase is also expressed the immune system of …
fundamental role in the hepatic urea cycle, arginase is also expressed the immune system of …
[HTML][HTML] Eukaryotic initiation factor 2 phosphorylation and translational control in metabolism
TD Baird, RC Wek - Advances in nutrition, 2012 - Elsevier
Regulation of mRNA translation is a rapid and effective means to couple changes in the
cellular environment with global rates of protein synthesis. In response to stresses, such as …
cellular environment with global rates of protein synthesis. In response to stresses, such as …
New insights into the roles of CHOP-induced apoptosis in ER stress
Y Li, Y Guo, J Tang, J Jiang, Z Chen - Acta Biochim Biophys Sin, 2014 - academic.oup.com
Endoplasmic reticulum stress (ER stress) is triggered due to a loss of homeostasis in the ER,
resulting in accumulation of misfolded proteins in the ER lumen. ER stress activates a series …
resulting in accumulation of misfolded proteins in the ER lumen. ER stress activates a series …
Transcription factor C/EBP homologous protein in health and diseases
Y Yang, L Liu, I Naik, Z Braunstein, J Zhong… - Frontiers in …, 2017 - frontiersin.org
C/EBP homologous protein (CHOP), known also as DNA damage-inducible transcript 3 and
as growth arrest and DNA damage-inducible protein 153 (GADD153), is induced in …
as growth arrest and DNA damage-inducible protein 153 (GADD153), is induced in …
TRB3, a novel ER stress‐inducible gene, is induced via ATF4–CHOP pathway and is involved in cell death
N Ohoka, S Yoshii, T Hattori, K Onozaki… - The EMBO …, 2005 - embopress.org
C/EBP homologous protein (CHOP) is a stress‐inducible nuclear protein that is crucial for
the development of programmed cell death and regeneration; however, the regulation of its …
the development of programmed cell death and regeneration; however, the regulation of its …