The transdifferentiation of epithelial cells into motile mesenchymal cells, a process known as
epithelial–mesenchymal transition (EMT), is integral in development, wound healing and …

Pluripotent embryonic stem cells (ESCs) can self-renew or differentiate into any cell type
within an organism. Here, we focus on the roles of cadherins and catenins–their cytoplasmic …

Long noncoding RNAs (lncRNAs) are often expressed in a development-specific manner,
yet little is known about their roles in lineage commitment. Here, we identified Braveheart …

Recent evidence has emerged that cancer cells can use various metabolites as fuel
sources. Restricting cultured cancer cells to sole metabolite fuel sources can promote …

Pluripotent cells have the potential to differentiate into all of the cell types of an animal. This
unique cell state is governed by an interconnected network of transcription factors. Among …

Neuromesodermal (NM) stem cells generate neural and paraxial presomitic mesoderm
(PSM) cells, which are the respective progenitors of the spinal cord and musculoskeleton of …

Objective Smoothened (SMO), a coreceptor of the Hedgehog (Hh) pathway, promotes
fibrogenic repair of chronic liver injury. We investigated the roles of SMO+ myofibroblast …

The interplay between the Yamanaka factors (OCT4, SOX2, KLF4 and c-MYC) and
transcriptional/epigenetic co-regulators in somatic cell reprogramming is incompletely …

The complex spatial and paracrine relationships between the various liver histotypes are
essential for proper functioning of the hepatic parenchymal cells. Only within a correct tissue …

Lung epithelial-mesenchymal transition (EMT) plays an important role in silicosis fibrosis.
The reverse process of EMT is mesenchymal-epithelial transition (MET), which is viewed as …