In this review, we analyze the effects of growth hormone on a number of tissues and organs
and its putative role in the longitudinal growth of an organism. We conclude that the …

Liver-expressed antimicrobial peptide 2 (LEAP-2), originally described as an antimicrobial
peptide, has recently been recognized as an endogenous blocker of growth hormone …

Infections and inflammation can lead to cachexia and wasting of skeletal muscle and fat
tissue by as yet poorly understood mechanisms. We observed that gut colonization of mice …

Growth hormone (GH) excess in acromegaly is associated with increased precancerous
colon polyps and soft tissue adenomas, whereas short-stature humans harboring an …

Results: The average degree of DNA methylation of all analyzed CpG sites was lower in fat
cells from post-obese as compared with never-obese women (P= 0.014). A total of 8504 …

Sex-dependent pituitary growth hormone (GH) secretory profiles—pulsatile in males and
persistent in females—regulate the sex-biased, STAT5-dependent expression of hundreds …

Despite the considerable body of evidence pointing to a possible relationship between the
state of the adipose tissue depots and regulation of the somatotropic axis, to date the …

Abstract Effects of the short peptides Ala-Glu-Asp (AED), Lys-Glu-Asp (KED) and Lys-Glu
(KE) on the expression of IGF1, FOXO1, TERT, TNKS2, and NFκB genes were studied in …

Insulin-like growth factor (IGF) signaling plays an important role in cell growth and
proliferation and is implicated in regulation of cancer, metabolism, and aging. Here we …

Glucocorticoids are essential hormones produced by the adrenal cortex with prominent
circadian rhythmicity and in times of stress. Glucocorticoids maintain liver homeostasis …