Natural killer cells (NK cells) are the first line of the innate immune defense system, primarily
located in peripheral circulation and lymphoid tissues. They kill virally infected and …

Bi-, tri-and multispecific antibodies have enabled the development of targeted cancer
immunotherapies redirecting immune effector cells to eliminate malignantly transformed …

Adoptive cellular immunotherapy using immune cells expressing chimeric antigen receptors
(CARs) has shown promise, particularly for the treatment of hematological malignancies. To …

Despite considerable progress has been achieved in the treatment of acute myeloid
leukemia over the past decades, relapse remains a major problem. Novel therapeutic …

Chimeric antigen receptor (CAR)-engineered T-cell (CAR-T) therapy has demonstrated
impressive therapeutic efficacy against hematological malignancies, but multiple challenges …

Immunotherapy based on natural killer (NK) cells is a promising approach for treating a
variety of cancers. Unlike T cells, NK cells recognize target cells via a major …

Natural killer (NK) cells are unique innate lymphoid cells that have therapeutic potential in
adoptive cell transfer-based cancer immunotherapy that has been established across a …

The discovery of human pluripotent stem cells (PSCs) at the turn of the century opened the
door to a new generation of regenerative medicine research. Among PSCs, the donors …

The advent of induced pluripotent stem cells (iPSCs) has advanced our understanding of the
molecular mechanisms of human disease, drug discovery, and regenerative medicine. As …

Simple Summary Natural Killer (NK) cells play a major role in cancer immunotherapy based
on tumor-targeting mAbs. NK cell-mediated tumor cell killing and cytokine secretion are …