[HTML][HTML] The traditional Chinese medicines treat chronic heart failure and their main bioactive constituents and mechanisms

J Chen, X Wei, Q Zhang, Y Wu, G Xia, H Xia… - … Pharmaceutica Sinica B, 2023 - Elsevier
Chronic heart failure (CHF) is a severe public health problem with increasing morbidity and
mortality, any treatment targeting a single session is insufficient to tackle this. CHF is …

[HTML][HTML] Damage mechanism and therapy progress of the blood-brain barrier after ischemic stroke

H Gao, H Chen, GY Cui, JX Hu - Cell & Bioscience, 2023 - Springer
The blood-brain barrier (BBB) serves as a defensive line protecting the central nervous
system, while also maintaining micro-environment homeostasis and inhibiting harmful …

[HTML][HTML] Panax notoginseng saponins alleviates inflammation induced by microglial activation and protects against ischemic brain injury via inhibiting HIF-1α/PKM2 …

J Gao, M Yao, W Zhang, B Yang, G Yuan, J Liu… - Biomedicine & …, 2022 - Elsevier
Panax notoginseng saponins (PNS), the main active ingredient of herbal medicine Panax
notoginseng, has been generally applied for the therapy of cardiovascular and …

[HTML][HTML] QiShen YiQi and its components attenuate acute thromboembolic stroke and carotid thrombosis by inhibition of CD62P/PSGL-1-mediated platelet-leukocyte …

M Yu, G Xiao, L Han, L Peng, H Wang, S He… - Biomedicine & …, 2023 - Elsevier
Abstract Background QiShen YiQi (QSYQ) dropping pill, a component-based Chinese
medicine consisting of benefiting Qi (YQ) and activating blood (HX) components, has been …

[HTML][HTML] The combination of Tanshinone IIA and Astragaloside IV attenuates myocardial ischemia–reperfusion injury by inhibiting the STING pathway

P Zhai, Q Chen, X Wang, X Ouyang, M Yang, Y Dong… - Chinese Medicine, 2024 - Springer
Abstract Background Astragaloside IV (As-IV) and Tanshinone IIA (Ta-IIA) are the main
ingredients of traditional Chinese medicinal Astragalus membranaceus (Fisch.) Bunge and …

[HTML][HTML] Qishen Yiqi Dropping Pill facilitates post-stroke recovery of motion and memory loss by modulating ICAM-1-mediated neuroinflammation

X Liu, G Xiao, Y Wang, T Shang, Z Li, H Wang… - Biomedicine & …, 2022 - Elsevier
Background Promotion of functional recovery in patients is the primary goal of stroke
management. However, its achievement is low due to the lack of full understanding of the …

Protective effects of Zishen Huoxue recipe against neuronal injury in the neurovascular unit of rats with vascular dementia by interfering with inflammatory cascade …

T Yao, L Xie, Y Xie, J Jiang, Q Deng, J Wang, L Liu… - Neuropeptides, 2023 - Elsevier
Objective Chinese herbal formulas show considerable therapeutic benefits in dementia. This
study specifically explored the protective action of Zishen Huoxue recipe on the …

[HTML][HTML] Spectrum effect correlation of yangyin tongnao granules on cerebral ischemia-reperfusion injury rats

Y Zhang, L Yu, J Yang, Z Ding, Y He… - Frontiers in …, 2022 - frontiersin.org
Yangyin Tongnao Granules (YYTNG), as traditional Chinese medicine (TCM) compound
preparation, have a good curative effect on cerebral ischemia-reperfusion injury. This study …

Proteomic advance of ischemic stroke: preclinical, clinical, and intervention

T Zhao, J Zeng, R Zhang, L Pu, H Wang, L Pan… - Metabolic Brain …, 2023 - Springer
Ischemic stroke (IS) is the most common type of stroke and is characterized by high rates of
mortality and long-term injury. The prediction and early diagnosis of IS are therefore crucial …

Network pharmacology and molecular docking prediction, combined with experimental validation to explore the potential mechanism of Qishen Yiqi pills against HF …

SJ Han, QQ Xu, WJ Liu, QQ Dai, HY Lin, HR Cui… - Journal of …, 2023 - Elsevier
Abstract Ethnopharmacological relevance Qishen Yiqi Pills (QSYQ) is a classical herbal
formula for treating heart failure (HF) and has potential efficacy in improving cognitive …