Osteoarthritis (OA) is a common degenerative disease characterized by the destruction of
articular cartilage and chronic inflammation of surrounding tissues. Matrix metalloproteinase …

Osteoarthritis (OA) is the most common joint disorder and affects approximately half of the
aged population. Current treatments for OA are largely palliative until the articular cartilage …

Metabolic osteoarthritis (OA) has now been characterized as a subtype of OA, and links
have been discovered between this phenotype and metabolic syndrome (MetS)—both with …

The global pandemic of obesity and type 2 diabetes is often causally linked to marked
changes in diet and lifestyle; namely marked increases in dietary intakes of high energy …

Osteoarthritis (OA) is a common joint condition that is a leading cause of disability
worldwide. There are currently no disease-modifying treatments for osteoarthritis, which is …

Human cartilage is a complex tissue of matrix proteins that vary in amount and orientation
from superficial to deep layers and from loaded to unloaded zones. A major challenge to …

Biomarkers are used as tools in cancer diagnostics and in treatment stratification. In most
cancers, there are increased levels of one or several members of the matrix …

Osteoarthritis (OA) is a prevalent disease of most mammalian species and is a significant
cause of welfare and economic morbidity in affected individuals and populations. In vitro …

Osteoarthritis (OA) is a heterogeneous disorder with several risk factors. Among them,
obesity has a major impact on both loading and non-loading joints. Mechanical overload …

INTRODUCTION: Osteoarthritis (OA) of the knee joint is caused by genetic and hormonal
factors and by inflammation, in combination with biomechanical alterations. It is …