The molecular basis of translation initiation and its regulation in eukaryotes
J Brito Querido, I Díaz-López… - Nature Reviews Molecular …, 2024 - nature.com
The regulation of gene expression is fundamental for life. Whereas the role of transcriptional
regulation of gene expression has been studied for several decades, it has been clear over …
regulation of gene expression has been studied for several decades, it has been clear over …
Advancements of in vitro transcribed mRNA (IVT mRNA) to enable translation into the clinics
The accelerated progress and approval of two mRNA-based vaccines to address the SARS-
CoV-2 virus were unprecedented. This record-setting feat was made possible through the …
CoV-2 virus were unprecedented. This record-setting feat was made possible through the …
The structure of a human translation initiation complex reveals two independent roles for the helicase eIF4A
J Brito Querido, M Sokabe, I Díaz-López… - Nature Structural & …, 2024 - nature.com
Eukaryotic translation initiation involves recruitment of the 43S pre-initiation complex to the
5′ end of mRNA by the cap-binding complex eIF4F, forming the 48S translation initiation …
5′ end of mRNA by the cap-binding complex eIF4F, forming the 48S translation initiation …
Enhancement of SARS-CoV-2 mRNA Vaccine Efficacy through the Application of TMSB10 UTR for Superior Antigen Presentation and Immune Activation
X Ding, Y Zhou, J He, J Zhao, J Li - Vaccines, 2024 - mdpi.com
The development of effective vaccines against SARS-CoV-2 remains a critical challenge
amidst the ongoing global pandemic. This study introduces a novel approach to enhancing …
amidst the ongoing global pandemic. This study introduces a novel approach to enhancing …
LINC01197 inhibits Influenza A Virus replication by serving as a PABPC1 decoy
Y Wang, N Shi, H Zhang, J Luo, H Yan, H Hou, Z Guan… - 2024 - researchsquare.com
Influenza A viruses (IAVs) are known to impose a significant impact on both animal and
human health due to its zoonotic potential. A growing body of evidence indicates that host …
human health due to its zoonotic potential. A growing body of evidence indicates that host …
[PDF][PDF] Molecular grammar of RNA-binding protein interactions in formation and func-tion of ribonucleoprotein complexes
M Adamek - Proceedings of Socratic Lectures - zf.uni-lj.si
Ribonucleoproteins (RNPs) are macromolecular assemblies of proteins along RNA
molecules to carry out specialized cellular processes. Understanding how RNA binding …
molecules to carry out specialized cellular processes. Understanding how RNA binding …