Novel small molecule therapeutic agents for Alzheimer disease: Focusing on BACE1 and multi-target directed ligands
Alzheimer's Disease (AD) is a progressive neurodegenerative disorder that effects 50 million
people worldwide. In this review, AD pathology and the development of novel therapeutic …
people worldwide. In this review, AD pathology and the development of novel therapeutic …
[HTML][HTML] Dihydrochalcones: Methods of acquisition and pharmacological properties—A first systematic review
M Stompor, D Broda, A Bajek-Bil - Molecules, 2019 - mdpi.com
Dihydrochalcones are a class of secondary metabolites, for which demand in biological and
pharmacological applications is still growing. They posses several health-endorsing …
pharmacological applications is still growing. They posses several health-endorsing …
Recent advances in the biosynthesis, bioavailability, toxicology, pharmacology, and controlled release of citrus neohesperidin
Abstract Neohesperidin (hesperetin 7-O-neohesperidoside), a well-known flavanone
glycoside widely found in citrus fruits, exhibits a variety of biological activities, with potential …
glycoside widely found in citrus fruits, exhibits a variety of biological activities, with potential …
Donepezil-inspired multitargeting indanone derivatives as effective anti-Alzheimer's agents
In continuous efforts to develop anti-Alzheimer's agents, we rationally designed and
synthesized a series of multitargeting molecules by incorporating the essential molecular …
synthesized a series of multitargeting molecules by incorporating the essential molecular …
Two new iridoid glycosides from Gardeniae Fructus
P Shu, M Yu, H Zhu, Y Luo, Y Li, N Li, H Zhang… - Carbohydrate …, 2021 - Elsevier
Two new iridoid glycosides, genipin 1, 10-di-O-α-l-rhamnoside (1) and genipin 1, 10-di-O-β-
d-xylopyranoside (2), along with thirteen known compounds (3–15) were isolated from …
d-xylopyranoside (2), along with thirteen known compounds (3–15) were isolated from …
Multi-target inhibition ability of neohesperidin dictates its neuroprotective activity: implication in Alzheimer's disease therapeutics
The polygenic nature of Alzheimer's disease (AD) and cross-talk between several signaling
cascades make it harder to decode the disease pathogenesis. β-secretase (BACE1) works …
cascades make it harder to decode the disease pathogenesis. β-secretase (BACE1) works …
The ameliorative effect of Piper trioicum in attenuating cognitive deficit in scopolamine induced neurotoxicity in experimental rats
UC Dash, SK Swain, AB Jena, J Dandapat… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance In traditional system of medicine, Piper species, or its
components are widely used to treat many diseases including memory improvement. One of …
components are widely used to treat many diseases including memory improvement. One of …
Scope of β-secretase (bace1)-targeted therapy in alzheimer's disease: Emphasizing the flavonoid based natural scaffold for bace1 inhibition
S Das, S Sengupta, S Chakraborty - ACS Chemical Neuroscience, 2020 - ACS Publications
Alzheimer's disease (AD) is a progressive neurodegenerative disease and the most
common form of dementia in the world. Studies report the presence of extracellular amyloid …
common form of dementia in the world. Studies report the presence of extracellular amyloid …
Advanced analytical methodologies in Alzheimer's disease drug discovery
Despite the constant progress in the understanding of the etiopathogenesis of Alzheimer's
disease (AD) over the last 50 years, just four long-standing drugs are currently used for AD …
disease (AD) over the last 50 years, just four long-standing drugs are currently used for AD …
Antiviral Flavonoids: A Natural Scaffold with Prospects as Phytomedicines against SARS-CoV2
C Saha, R Naskar, S Chakraborty - Mini Reviews in Medicinal …, 2024 - ingentaconnect.com
Flavonoids are vital candidates to fight against a wide range of pathogenic microbial
infections. Due to their therapeutic potential, many flavonoids from the herbs of traditional …
infections. Due to their therapeutic potential, many flavonoids from the herbs of traditional …