Novel small molecule therapeutic agents for Alzheimer disease: Focusing on BACE1 and multi-target directed ligands

A Iraji, M Khoshneviszadeh, O Firuzi… - Bioorganic …, 2020 - Elsevier
Alzheimer's Disease (AD) is a progressive neurodegenerative disorder that effects 50 million
people worldwide. In this review, AD pathology and the development of novel therapeutic …

[HTML][HTML] Dihydrochalcones: Methods of acquisition and pharmacological properties—A first systematic review

M Stompor, D Broda, A Bajek-Bil - Molecules, 2019 - mdpi.com
Dihydrochalcones are a class of secondary metabolites, for which demand in biological and
pharmacological applications is still growing. They posses several health-endorsing …

Recent advances in the biosynthesis, bioavailability, toxicology, pharmacology, and controlled release of citrus neohesperidin

S Akhter, MSI Arman, MA Tayab… - Critical Reviews in …, 2022 - Taylor & Francis
Abstract Neohesperidin (hesperetin 7-O-neohesperidoside), a well-known flavanone
glycoside widely found in citrus fruits, exhibits a variety of biological activities, with potential …

Donepezil-inspired multitargeting indanone derivatives as effective anti-Alzheimer's agents

JV Singh, S Thakur, N Kumar, H Singh… - ACS Chemical …, 2022 - ACS Publications
In continuous efforts to develop anti-Alzheimer's agents, we rationally designed and
synthesized a series of multitargeting molecules by incorporating the essential molecular …

Two new iridoid glycosides from Gardeniae Fructus

P Shu, M Yu, H Zhu, Y Luo, Y Li, N Li, H Zhang… - Carbohydrate …, 2021 - Elsevier
Two new iridoid glycosides, genipin 1, 10-di-O-α-l-rhamnoside (1) and genipin 1, 10-di-O-β-
d-xylopyranoside (2), along with thirteen known compounds (3–15) were isolated from …

Multi-target inhibition ability of neohesperidin dictates its neuroprotective activity: implication in Alzheimer's disease therapeutics

S Chakraborty, J Rakshit, J Bandyopadhyay… - International Journal of …, 2021 - Elsevier
The polygenic nature of Alzheimer's disease (AD) and cross-talk between several signaling
cascades make it harder to decode the disease pathogenesis. β-secretase (BACE1) works …

The ameliorative effect of Piper trioicum in attenuating cognitive deficit in scopolamine induced neurotoxicity in experimental rats

UC Dash, SK Swain, AB Jena, J Dandapat… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance In traditional system of medicine, Piper species, or its
components are widely used to treat many diseases including memory improvement. One of …

Scope of β-secretase (bace1)-targeted therapy in alzheimer's disease: Emphasizing the flavonoid based natural scaffold for bace1 inhibition

S Das, S Sengupta, S Chakraborty - ACS Chemical Neuroscience, 2020 - ACS Publications
Alzheimer's disease (AD) is a progressive neurodegenerative disease and the most
common form of dementia in the world. Studies report the presence of extracellular amyloid …

Advanced analytical methodologies in Alzheimer's disease drug discovery

A De Simone, M Naldi, D Tedesco, M Bartolini… - … of Pharmaceutical and …, 2020 - Elsevier
Despite the constant progress in the understanding of the etiopathogenesis of Alzheimer's
disease (AD) over the last 50 years, just four long-standing drugs are currently used for AD …

Antiviral Flavonoids: A Natural Scaffold with Prospects as Phytomedicines against SARS-CoV2

C Saha, R Naskar, S Chakraborty - Mini Reviews in Medicinal …, 2024 - ingentaconnect.com
Flavonoids are vital candidates to fight against a wide range of pathogenic microbial
infections. Due to their therapeutic potential, many flavonoids from the herbs of traditional …