Oxidative stress in skin plays a major role in the aging process. This is true for intrinsic aging
and even more for extrinsic aging. Although the results are quite different in dermis and …

Chronic exposure to UVR is known to disrupt tissue homeostasis, accelerate the onset of
age-related phenotypes, and increase the risk for skin cancer—a phenomenon defined as …

The skin protects mammals from insults, infection and dehydration and enables
thermoregulation and sensory perception. Various skin-resident cells carry out these diverse …

The stroma in solid tumors contains a variety of cellular phenotypes and signaling pathways
associated with wound healing, leading to the concept that a tumor behaves as a wound that …

Despite the growing interest by researchers into cellular senescence, a hallmark of cellular
aging, its role in human skin remains equivocal. The skin is the largest and most accessible …

The skin is comprised of different cell types with different proliferative capacities. Skin aging
occurs with chronological age and upon exposure to extrinsic factors such as photodamage …

Loss of functionality during aging of cells and organisms is caused and accompanied by
altered cell-to-cell communication and signalling. One factor thereby is the chronic …

The growing incidence of melanoma is a serious public health issue that merits a thorough
understanding of potential causative risk factors, which includes exposure to ultraviolet …

Determination of the role of insulin-like growth factor (IGF) family components in
carcinogenesis of several human tumors is based on numerous epidemiological and pre …

Chronic, unhealed diabetic foot ulcer (DFU) is one of the most severe complications of
diabetes mellitus (DM). Naringin, a flavanone glycoside antioxidant, was reported to have …