Altered pronociceptive and antinociceptive mechanisms are often implicated in painful
conditions and have been increasingly studied over the past decade. For some painful …

This preclinical systematic review aimed to determine the effectiveness of different types and
doses of exercise on pain behavior and biomarkers in preclinical models of focal …

Back pain is linked to intervertebral disc (IVD) degeneration, but clinical studies show the
relationship is complex. This study assessed whether males and females have distinct …

Low back pain (LBP) has been inconsistently associated with enhanced pronociceptive and
impaired antinociceptive mechanisms. It remains unknown whether alterations are causal …

Purpose Prior data has set the precedent that female patients fare somewhat worse than
men after spine surgery. We aimed to evaluate the effect of gender on patient-reported …

Background Lumbar disc herniation (LDH) may induce radicular pain, the upregulation of
voltage-gated sodium channels (VGSCs) in dorsal root ganglion (DRG) contributes to …

Background The role of healthy lifestyle behavior (HLB) in terms of physical activity, alcohol
intake, smoking, and diet put together has not yet been explored for the risk of low back pain …

1. Background Entrapment neuropathies represent the most prevalent peripheral
neuropathy and are the most common cause of neuropathic pain (neuP). Carpal tunnel …

Objectives: To evaluate the depression and anxiety status and related risk factors in patients
with lumbar disc herniation, and help spine surgeons better identify those patients who need …

Objective To investigate the pattern of experimental pain responses at acupoints in patients
with unilateral shoulder pain. Design A cross-sectional matched study. Setting Acupuncture …