[HTML][HTML] Aspalathin alleviates skeletal muscle insulin resistance and mitochondrial dysfunction
SE Mazibuko-Mbeje, SXH Mthembu… - Physiological …, 2022 - ncbi.nlm.nih.gov
Natural compounds may bear promising therapeutic benefits against metabolic diseases
such as type 2 diabetes mellitus (T2DM), which are characterized by a state of insulin …
such as type 2 diabetes mellitus (T2DM), which are characterized by a state of insulin …
Aspalathin-rich green Aspalathus linearis extract suppresses migration and invasion of human castration-resistant prostate cancer cells via inhibition of YAP signaling
SH Huang, YH Kao, CJF Muller, E Joubert, CP Chuu - Phytomedicine, 2020 - Elsevier
Background More than 80% of advanced prostate cancer (PCa) cases have bone
metastasis, with a 5-year survival rate of 25%. Previously, we reported that GRT, a …
metastasis, with a 5-year survival rate of 25%. Previously, we reported that GRT, a …
[HTML][HTML] Pharmacokinetic interaction of green rooibos extract with atorvastatin and metformin in rats
O Patel, CJF Muller, E Joubert, B Rosenkranz… - Frontiers in …, 2019 - frontiersin.org
An aspalathin-rich green rooibos extract (Afriplex GRT™) has demonstrated anti-diabetic
and hypolipidemic properties, while also moderately inhibiting CYP3A4 activity, suggesting …
and hypolipidemic properties, while also moderately inhibiting CYP3A4 activity, suggesting …
Differential cytotoxicity of rooibos and green tea extracts against primary rat hepatocytes and human liver and colon cancer cells–causal role of major flavonoids
S Samodien, M Kock, E Joubert… - Nutrition and …, 2021 - Taylor & Francis
Differential anti-proliferative and pro-apoptotic effects of aqueous extracts of green rooibos
(Rg; Aspalathus linearis) and green tea (GT; Camellia sinensis) and an aspalathin-enriched …
(Rg; Aspalathus linearis) and green tea (GT; Camellia sinensis) and an aspalathin-enriched …
[HTML][HTML] Afriplex GRTTM extract attenuates hepatic steatosis in an in vitro model of NAFLD
K Gabuza, TI Mabuda, O Patel, N Khuboni… - Plos one, 2024 - journals.plos.org
Background Currently, it is acknowledged that vitamin E, insulin sensitizers and anti-diabetic
drugs are used to manage non-alcoholic fatty liver disease (NAFLD), however, these …
drugs are used to manage non-alcoholic fatty liver disease (NAFLD), however, these …
Inulin as microencapsulating agent improves physicochemical properties of spray-dried aspalathin-rich green rooibos (Aspalathus linearis) extract with α-glucosidase …
Limiting aspalathin degradation during spray-drying of green rooibos extract (GRE) is crucial
to produce a functional food ingredient with antidiabetic properties. Retention of aspalathin …
to produce a functional food ingredient with antidiabetic properties. Retention of aspalathin …
Moringa oleifera Lam. as a potential plant for alleviation of the metabolic syndrome—A narrative review based on in vivo and clinical studies
S Adarthaiya, A Sehgal - Phytotherapy Research, 2024 - Wiley Online Library
The metabolic syndrome (MetS) refers to the co‐occurrence of risk factors, including
hyperglycaemia, increased body weight, hypertension and dyslipidemia, which eventually …
hyperglycaemia, increased body weight, hypertension and dyslipidemia, which eventually …
Pharmacological activity of Aspalathus linearis extracts: pre-clinical research in view of prospective neuroprotection
J Pyrzanowska - Nutritional Neuroscience, 2023 - Taylor & Francis
Objectives Rooibos tea, a very popular everyday beverage made of Aspalathus linearis
plant material and containing multiple polyphenolic compounds, reveals an expectation to …
plant material and containing multiple polyphenolic compounds, reveals an expectation to …
Aspalathin, a C-glucosyldihydrochalcone from rooibos improves the hypoglycemic potential of metformin in type 2 diabetic (db/db) mice
PV Dludla, KB Gabuza, CJF Muller, E Joubert, J Louw… - 2018 - scholar.sun.ac.za
Metformin is the first line therapy of type 2 diabetics, but continued reduction of their life
expectancy warrants further investigation into alternative treatment strategies. This study …
expectancy warrants further investigation into alternative treatment strategies. This study …
Cardioprotective function of green Rooibos (Aspalathus linearis) extract supplementation in ex vivo ischemic prediabetic rat hearts
Diabetic patients develop ischemic heart disease and strokes more readily. Following an
ischemic event, restoration of blood flow increases oxidative stress resulting in myocardial …
ischemic event, restoration of blood flow increases oxidative stress resulting in myocardial …