Opportunities and challenges for use of tumor spheroids as models to test drug delivery and efficacy
Multicellular spheroids are three dimensional in vitro microscale tissue analogs. The current
article examines the suitability of spheroids as an in vitro platform for testing drug delivery …
article examines the suitability of spheroids as an in vitro platform for testing drug delivery …
In vitro cell migration and invasion assays
N Kramer, A Walzl, C Unger, M Rosner… - … Research/Reviews in …, 2013 - Elsevier
Determining the migratory and invasive capacity of tumor and stromal cells and clarifying the
underlying mechanisms is most relevant for novel strategies in cancer diagnosis, prognosis …
underlying mechanisms is most relevant for novel strategies in cancer diagnosis, prognosis …
Recent advances in three‐dimensional multicellular spheroid culture for biomedical research
Many types of mammalian cells can aggregate and differentiate into 3‐D multicellular
spheroids when cultured in suspension or a nonadhesive environment. Compared to …
spheroids when cultured in suspension or a nonadhesive environment. Compared to …
The use of 3-D cultures for high-throughput screening: the multicellular spheroid model
LA Kunz-Schughart, JP Freyer… - Journal of …, 2004 - journals.sagepub.com
Over the past few years, establishment and adaptation of cell-based assays for drug
development and testing has become an important topic in high-throughput screening …
development and testing has become an important topic in high-throughput screening …
Experimental anti-tumor therapy in 3-D: spheroids–old hat or new challenge?
J Friedrich, R Ebner… - International journal of …, 2007 - Taylor & Francis
Purpose: To give a state-of-the-art overview on the promise of three-dimensional (3-D)
culture systems for anticancer drug development, with particular emphasis on multicellular …
culture systems for anticancer drug development, with particular emphasis on multicellular …
3D tumor models: history, advances and future perspectives
P Benien, A Swami - Future oncology, 2014 - Future Medicine
Evaluation of cancer therapeutics by utilizing 3D tumor models, before clinical studies, could
be more advantageous than conventional 2D tumor models (monolayer cultures). The 3D …
be more advantageous than conventional 2D tumor models (monolayer cultures). The 3D …
Potential of fibroblasts to regulate the formation of three-dimensional vessel-like structures from endothelial cells in vitro
LA Kunz-Schughart, JA Schroeder… - … of Physiology-Cell …, 2006 - journals.physiology.org
The development of vessel-like structures in vitro to mimic as well as to realize the possibility
of tissue-engineered small vascular networks presents a major challenge to cell biologists …
of tissue-engineered small vascular networks presents a major challenge to cell biologists …
Enzymatic crosslinked hydrogels for biomedical application
E Badali, M Hosseini, M Mohajer… - … science, series A, 2021 - Springer
Self-assembled structures primarily arise through enzyme-regulated phenomena in nature
under persistent conditions. Enzymatic reactions are one of the main biological processes …
under persistent conditions. Enzymatic reactions are one of the main biological processes …
Three-dimensional cell culture technique and pathophysiology
M Matsusaki, CP Case, M Akashi - Advanced Drug Delivery Reviews, 2014 - Elsevier
Abstract Three-dimensional (3D) tissue constructs consisting of human cells have opened a
new avenue for tissue engineering, pharmaceutical and pathophysiological applications …
new avenue for tissue engineering, pharmaceutical and pathophysiological applications …
Challenges in bio-fabrication of organoid cultures
Abstract Three-dimensional (3D) organoids have shown advantages in cell culture over
traditional two-dimensional (2D) culture, and have great potential in various applications of …
traditional two-dimensional (2D) culture, and have great potential in various applications of …