Cancer cell spheroids for screening of chemotherapeutics and drug-delivery systems
NR Patel, B Aryasomayajula, AH Abouzeid… - Therapeutic …, 2015 - Future Science
Over the last few decades, the most popular platform to perform high-throughput screening
for viable anti-neoplastic compounds has been monolayer cell culture. However, cells in …
for viable anti-neoplastic compounds has been monolayer cell culture. However, cells in …
Two-dimensional vs. three-dimensional in vitro tumor migration and invasion assays
M Zimmermann, C Box, SA Eccles - Target Identification and Validation in …, 2013 - Springer
Motility and invasion are key hallmarks that distinguish benign from malignant tumors,
enabling cells to cross tissue boundaries, disseminate in blood and lymph and establish …
enabling cells to cross tissue boundaries, disseminate in blood and lymph and establish …
Production of hyaluronic‐acid‐based cell‐enclosing microparticles and microcapsules via enzymatic reaction using a microfluidic system
M Khanmohammadi, S Sakai… - Journal of Applied …, 2016 - Wiley Online Library
This article describes the preparation of cell‐enclosing hyaluronic acid (HA) microparticles
with solid core and microcapsules with liquid core through cell‐friendly horseradish …
with solid core and microcapsules with liquid core through cell‐friendly horseradish …
Rapid aggregation of heterogeneous cells and multiple-sized microspheres in methylcellulose medium
N Kojima, S Takeuchi, Y Sakai - Biomaterials, 2012 - Elsevier
We report a method for the rapid production of cellular aggregates without electric power
and cell modification. We focused on the swelling property of a solution containing a high …
and cell modification. We focused on the swelling property of a solution containing a high …
Spheroid confrontation assay: a simple method to monitor the three-dimensional migration of different cell types in vitro
K Hattermann, J Held-Feindt, R Mentlein - Annals of Anatomy …, 2011 - Elsevier
Cell migration and tissue invasion is an important issue in tumour and developmental
research. Here, we describe the spheroid invasion assay in detail, a method for monitoring …
research. Here, we describe the spheroid invasion assay in detail, a method for monitoring …
Construction of higher-order cellular microstructures by a self-wrapping co-culture strategy using a redox-responsive hydrogel
W Ramadhan, G Kagawa, K Moriyama… - Scientific reports, 2020 - nature.com
In this report, a strategy for constructing three-dimensional (3D) cellular architectures
comprising viable cells is presented. The strategy uses a redox-responsive hydrogel that …
comprising viable cells is presented. The strategy uses a redox-responsive hydrogel that …
Fabrication of microchannel networks in multicellular spheroids
N Kojima, S Takeuchi, Y Sakai - Sensors and Actuators B: Chemical, 2014 - Elsevier
Multicellular spheroids are indispensable in cell biology as three-dimensional environments,
in tissue engineering for achieving higher functions, and in drug validation by …
in tissue engineering for achieving higher functions, and in drug validation by …
Organotypic spheroid cultures to study tumor–stroma interaction during cancer development
H Dolznig, A Walzl, N Kramer, M Rosner… - Drug Discovery Today …, 2011 - Elsevier
Metastasis, which is linked to the invasive properties acquired by the primary tumor during
cancer progression, is the major life-threatening event in cancer patients. There is …
cancer progression, is the major life-threatening event in cancer patients. There is …
Enhancement of vinorelbine-induced cytotoxicity and apoptosis by clomipramine and lithium chloride in human neuroblastoma cancer cell line SH-SY5Y
The aim of this work is to investigate whether clomipramine (CIM) and lithium chloride (LiCl)
potentiate the cytotoxicity of vinorelbine (VNR) on SH-SY5Y human neuroblastoma cells in …
potentiate the cytotoxicity of vinorelbine (VNR) on SH-SY5Y human neuroblastoma cells in …
Fabrication of multi‐well chips for spheroid cultures and implantable constructs through rapid prototyping techniques
ABSTRACT Three‐dimensional (3D) culture models are widely used in basic and
translational research. In this study, to generate and culture multiple 3D cell spheroids, we …
translational research. In this study, to generate and culture multiple 3D cell spheroids, we …