The data landscape in preclinical safety assessment is fundamentally changing because of
not only emerging new data types, such as human systems biology, or real-world data …

Lung cancer is the prime cause of cancer-related deaths globally, with a contribution of 85%
from non-small cell lung cancer. Before a few decades back, conventional chemotherapy …

Regulatory agencies encourage computer modeling and simulation to reduce the time and
cost of clinical trials. Although still not classified in formal guidelines, system biology-based …

Emicizumab is a bispecific monoclonal antibody that substitutes for the function of missing or
deficient factor VIII (FVIII) in people with hemophilia A (PwHA). Long-term safety and efficacy …

Purpose Alectinib and brigatinib are second-generation anaplastic lymphoma receptor
tyrosine kinases (ALKs) that are widely used as first-line therapy for treating ALK-positive …

Oncology treatments require continuous individual adjustment based on the measurement
of multiple clinical parameters. Prediction tools exploiting the patterns present in the clinical …

Background Chronic spontaneous urticaria (CSU) is a rare, heterogeneous, severely
debilitating, and often poorly controlled skin disease resulting in an itchy eruption which can …

Eltrombopag is a thrombopoietin receptor (MPL) agonist approved for the treatment of
primary immune thrombocytopenia (ITP). Recent evidence shows that some patients may …

Acute respiratory distress syndrome (ARDS), associated with high mortality rate, affects up to
67% of hospitalized COVID-19 patients. Early evidence indicated that the pathogenesis of …

Ceritinib is a second-generation ALK TKI, and in a murine experiment, the blood-to-brain
transition ratio of ceritinib reached 15%(11). In the phase I trial (ASCEND-1), ceritinib …