Systemic sclerosis (SSc) is a destructive connective tissue disease characterized by
dysregulation of the immune system and fibrosis in the skin and internal organs. The …

In recent studies, NKG2A is revealed to be a key immune checkpoint for both natural killer
(NK) cells and CD8+ T cells. It form heterodimer receptors with CD94, and targets the …

Improved approaches to expanding the pool of donor lungs suitable for transplantation are
critically needed for the growing population with end-stage lung disease. Cross-circulation …

Short-stranded miRNAs are single-stranded RNA molecules involved in the regulation of
gene expression. miRNAs are involved in a variety of cellular physiological processes …

Studies investigating the immunopathology of multiple sclerosis (MS) have largely focused
on adaptive T and B lymphocytes. However, in recent years there has been an increased …

Natural killer (NK) cells, in addition to their cytotoxicity function, harbor prominent cytokine
production capabilities and contribute to regulating autoimmune responses. T-cell …

MYC is a pleiotropic transcription factor involved in cancer, cell proliferation, and
metabolism. Its regulation and function in NK cells, which are innate cytotoxic lymphocytes …

Sjögrens syndrome (SS) is caused by autoantibodies that attack proprioceptive salivary and
lacrimal gland tissues. Damage to the glands leads to dry mouth and eyes and affects …

Objective CD38 is a type II glycoprotein highly expressed on plasmablasts and on short-and
long-lived plasma cells, but weakly expressed by lymphoid, myeloid, and non-hematopoietic …

Glucocorticoids exert their pharmacological actions by mimicking and amplifying the function
of the endogenous glucocorticoid system's canonical physiological stress response. They …