Ligand‐installed nanocarriers toward precision therapy
Abstract Development of drug‐delivery systems that selectively target neoplastic cells has
been a major goal of nanomedicine. One major strategy for achieving this milestone is to …
been a major goal of nanomedicine. One major strategy for achieving this milestone is to …
The latest battles between EGFR monoclonal antibodies and resistant tumor cells
WQ Cai, LS Zeng, LF Wang, YY Wang, JT Cheng… - Frontiers in …, 2020 - frontiersin.org
Epidermal growth factor receptor (EGFR) is a tyrosine kinase receptor involved in
homeostatic regulation of normal cells and carcinogenesis of epithelial malignancies. With …
homeostatic regulation of normal cells and carcinogenesis of epithelial malignancies. With …
Antitumor Activity of Amivantamab (JNJ-61186372), an EGFR–MET Bispecific Antibody, in Diverse Models of EGFR Exon 20 Insertion–Driven NSCLC
J Yun, SH Lee, SY Kim, SY Jeong, JH Kim, KH Pyo… - Cancer Discovery, 2020 - AACR
EGFR exon 20 insertion driver mutations (Exon20ins) in non–small cell lung cancer
(NSCLC) are insensitive to EGFR tyrosine kinase inhibitors (TKI). Amivantamab (JNJ …
(NSCLC) are insensitive to EGFR tyrosine kinase inhibitors (TKI). Amivantamab (JNJ …
The role of imaging in targeted delivery of nanomedicine for cancer therapy
P Li, D Wang, J Hu, X Yang - Advanced Drug Delivery Reviews, 2022 - Elsevier
Nanomedicines overcome the pharmacokinetic limitations of traditional drug formulations
and have promising prospect in cancer treatment. However, nanomedicine delivery in vivo is …
and have promising prospect in cancer treatment. However, nanomedicine delivery in vivo is …
Epidermal growth factor receptor targeting in cancer: a review of trends and strategies
The epidermal growth factor receptor (EGFR) is a cell-surface receptor belonging to ErbB
family of tyrosine kinase and it plays a vital role in the regulation of cell proliferation, survival …
family of tyrosine kinase and it plays a vital role in the regulation of cell proliferation, survival …
Boron agents for neutron capture therapy
K Hu, Z Yang, L Zhang, L Xie, L Wang, H Xu… - Coordination Chemistry …, 2020 - Elsevier
Boron neutron capture therapy (BNCT) is a potential cancer radiotherapeutic modality,
which takes advantage of the neutron capture response that occurs when boron (10 B) is …
which takes advantage of the neutron capture response that occurs when boron (10 B) is …
Understanding resistance to EGFR inhibitors—impact on future treatment strategies
DL Wheeler, EF Dunn, PM Harari - Nature reviews Clinical oncology, 2010 - nature.com
EGFR is a tyrosine kinase that participates in the regulation of cellular homeostasis.
Following ligand binding, EGFR stimulates downstream cell signaling cascades that …
Following ligand binding, EGFR stimulates downstream cell signaling cascades that …
Pharmaceutical applications of electrospraying
The electrohydrodynamic atomization technique, or simply called electrospraying, has been
extensively studied for biomedical as well as for pharmaceutical applications over the past …
extensively studied for biomedical as well as for pharmaceutical applications over the past …
Au nanoparticles target cancer
PK Jain, IH El-Sayed, MA El-Sayed - nano today, 2007 - Elsevier
Nanoparticles with unique optical properties, facile surface chemistry, and appropriate size
scale are generating much enthusiasm in molecular biology and medicine. Noble metal …
scale are generating much enthusiasm in molecular biology and medicine. Noble metal …
Comparing antibody and small-molecule therapies for cancer
K Imai, A Takaoka - Nature Reviews Cancer, 2006 - nature.com
The'magic bullet'concept of specifically targeting cancer cells at the same time as sparing
normal tissues is now proven, as several monoclonal antibodies and targeted small …
normal tissues is now proven, as several monoclonal antibodies and targeted small …