The process of epithelial–mesenchymal transition (EMT) is fundamental for embryonic
morphogenesis. Cells undergoing it lose epithelial characteristics and integrity, acquire …

In order to meet the high energy demand, a metabolic reprogramming occurs in cancer cells.
Its role is crucial in promoting tumor survival. Among the substrates in demand, oxygen is …

Recurrent mutations in isocitrate dehydrogenase 2 (IDH2) occur in∼ 12% of patients with
acute myeloid leukemia (AML). Mutated IDH2 proteins neomorphically synthesize 2 …

The transition between epithelial and mesenchymal phenotype is emerging as a key
determinant of tumor cell invasion and metastasis. It is a plastic process in which epithelial …

Epithelial-mesenchymal transition (EMT) and its critical roles during cancer progression
have long been recognized and extensively reviewed. Recent studies on the generation of …

Cancer cell metabolism including aerobic glycolysis, amino acid and fatty acid metabolism,
has been extensively studied. Metabolic reprogramming is a major hallmark of cancer …

Triple-negative breast cancer (TNBC) is a difficult-to-treat, aggressive cancer type. TNBC is
often associated with the cellular program of epithelial-mesenchymal transition (EMT) that …

Metabolic reprogramming and metabolic plasticity allow cancer cells to fine-tune their
metabolism and adapt to the ever-changing environments of the metastatic cascade, for …

Connective tissue is known to provide structural and functional “glue” properties to other
tissues. It contains cellular and molecular components that are arranged in several dynamic …

Growing evidence highlights that glycolysis and tumor-derived lactate could skew tumor-
associated macrophages (TAMs) toward an immunosuppressive phenotype. However, the …