Immune response, inflammation, and the clinical spectrum of COVID-19

LF García - Frontiers in immunology, 2020 - frontiersin.org
The current COVID-19 pandemic began in December 2019 in Wuhan (China) and rapidly
extended to become a global sanitary and economic emergency. Its etiological agent is the …

Persistent poor health after COVID-19 is not associated with respiratory complications or initial disease severity

L Townsend, J Dowds, K O'Brien, G Sheill… - Annals of the …, 2021 - atsjournals.org
Rationale: Much is known about the acute infective process of severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), the causative virus of the coronavirus disease …

Local and systemic responses to SARS-CoV-2 infection in children and adults

M Yoshida, KB Worlock, N Huang, RGH Lindeboom… - Nature, 2022 - nature.com
It is not fully understood why COVID-19 is typically milder in children,–. Here, to examine the
differences between children and adults in their response to SARS-CoV-2 infection, we …

Analysis of SARS-CoV-2 vertical transmission during pregnancy

C Fenizia, M Biasin, I Cetin, P Vergani, D Mileto… - Nature …, 2020 - nature.com
The impact of SARS-CoV-2 infection during gestation remains unclear. Here, we analyse the
viral genome on maternal and newborns nasopharyngeal swabs, vaginal swabs, maternal …

Innate immune and inflammatory responses to SARS-CoV-2: Implications for COVID-19

SA Lowery, A Sariol, S Perlman - Cell Host & Microbe, 2021 - cell.com
COVID-19 can result in severe disease characterized by significant immunopathology that is
spurred by an exuberant, yet dysregulated, innate immune response with a poor adaptive …

[HTML][HTML] Persistence of SARS CoV-2 S1 protein in CD16+ monocytes in post-acute sequelae of COVID-19 (PASC) up to 15 months post-infection

BK Patterson, EB Francisco, R Yogendra… - Frontiers in …, 2022 - frontiersin.org
The recent COVID-19 pandemic is a treatment challenge in the acute infection stage but the
recognition of chronic COVID-19 symptoms termed post-acute sequelae SARS-CoV-2 …

Immunological and inflammatory profiles in mild and severe cases of COVID-19

JW Song, C Zhang, X Fan, FP Meng, Z Xu, P Xia… - Nature …, 2020 - nature.com
Abstract COVID-19 is associated with 5.1% mortality. Although the virological,
epidemiological, clinical, and management outcome features of COVID-19 patients have …

Effective treatment of severe COVID-19 patients with tocilizumab

X Xu, M Han, T Li, W Sun, D Wang… - Proceedings of the …, 2020 - National Acad Sciences
After analyzing the immune characteristics of patients with severe coronavirus disease 2019
(COVID-19), we have identified that pathogenic T cells and inflammatory monocytes with …

Post-COVID-19 fatigue: A systematic review

J Joli, P Buck, S Zipfel, A Stengel - Frontiers in psychiatry, 2022 - frontiersin.org
Fatigue is recognized as one of the most commonly presented long-term complaints in
individuals previously infected with SARS-CoV-2. This systematic review was performed to …

Why tocilizumab could be an effective treatment for severe COVID-19?

B Fu, X Xu, H Wei - Journal of translational medicine, 2020 - Springer
A severe pneumonia-associated respiratory syndrome caused by a new coronavirus was
identified in December 2019 (COVID-19), spread rapidly and has become a world-wide …