Puberty marks the end of childhood and is a period when individuals undergo physiological
and psychological changes to achieve sexual maturation and fertility. The hypothalamic …

Central precocious puberty (CPP) results from early activation of the hypothalamic‐pituitary‐
gonadal (HPG) axis. The current state of knowledge of the complex neural network acting at …

Objective Neurokinin (NK)-3 and NK-1 receptors have been implicated in the etiology of
vasomotor symptoms (VMS) and sleep disturbances associated with menopause. This …

BACKGROUND Puberty is a complex developmental event, controlled by sophisticated
regulatory networks that integrate peripheral and internal cues and impinge at the brain …

Tachykinins are comprised of the family of related peptides, substance P (SP), neurokinin A
(NKA), and neurokinin B (NKB). NKB has emerged as regulator of kisspeptin release in the …

Objectives: To evaluate the safety, pharmacokinetics, and preliminary efficacy of NT-814, a
dual neurokinin 1, 3 antagonist, in postmenopausal women with vasomotor symptoms (hot …

Highly sophisticated and synchronized interactions of various cells and hormonal signals
are required to make organisms competent for reproduction. GnRH neurons act as a …

A reliable, easy to assess marker for fertility in agricultural species would be highly desirable
and Anti-Müllerian Hormone (AMH) is a promising candidate. This review summarizes …

Hypothalamic peptidergic neurons using kisspeptin (KP) and its co-transmitters for
communication are critically involved in the regulation of mammalian reproduction and …

Hypothalamic kisspeptin (KP) neurons are key players in the neuronal network that
regulates the onset of puberty and the pulsatile secretion of gonadotropin-releasing …