Peroxisome proliferator–activated receptor α (PPAR α) is a nuclear receptor of clinical
interest as a drug target in various metabolic disorders. PPAR α also exhibits marked anti …

Bile acids are amphipathic molecules synthesized from cholesterol in the liver. Bile acid
synthesis is a major pathway for hepatic cholesterol catabolism. Bile acid synthesis …

The gut microbiota is essential for numerous aspects of human health. However, the
underlying mechanisms of many host-microbiota interactions remain unclear. The aim of this …

The objective of this study was to investigate the effect of Lactobacillus acidophilus ATCC
4356 on the development of atherosclerosis in apolipoprotein E-knockout (ApoE−/−) mice …

The discovery of adipose triglyceride lipase (ATGL) and its coactivator comparative gene
identification-58 (CGI-58) provided a major paradigm shift in the understanding of …

The aim of the present study was to examine whether pretreatment with different fatty acids,
as well as the liver X receptor (LXR) agonist T0901317, could modify metabolic switching of …

Liver X receptor (LXR) α and β are nuclear receptors that control cellular metabolism. LXRs
modulate the expression of genes involved in cholesterol and lipid metabolism in response …

Aims Peroxisome proliferator-activated receptor (PPAR)-α is a transcription factor controlling
lipid metabolism in liver, heart, muscle, and macrophages. Peroxisome proliferator-activated …

The liver X receptors (LXR) are crucial regulators of metabolism. After ligand binding, they
regulate gene transcription and thereby mediate changes in metabolic pathways …

Liver X receptor (LXR) activation improves glucose homeostasis in obesity. This
improvement, however, is associated with several side effects including hyperlipidemia and …