Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease
and may progress to cirrhosis or even hepatocellular carcinoma. A number of steroid …

Our immune system has evolved as a complex network of cells and tissues tasked with
maintaining host homeostasis. This is evident during the inflammatory responses elicited …

Conclusions Our study demonstrates a mixed fibrinolytic phenotype in acutely ill patients
with cirrhosis with baseline hypofibrinolysis associated with sepsis, organ failure, and short …

Nuclear receptors are ligand-activated transcription factors that regulate gene expression of
a variety of key molecular signals involved in liver fibrosis. The primary cellular driver of liver …

Increased consumption of high-caloric carbohydrates contributes substantially to endemic
non-alcoholic fatty liver disease in humans, covering a histological spectrum from fatty liver …

Background and Aims Hepatic endoplasmic reticulum (ER) stress, whether triggered by
intrinsic or extrinsic factors, can be resolved by the unfolded protein response (UPR) …

Glucocorticoids are steroid hormones that are of pivotal importance in human physiology.
Glucocorticoid signaling is complex in nature and dependent on many interacting factors. As …

Alcoholic hepatitis is a major health and economic burden worldwide. Glucocorticoids (GCs)
are the only first-line drugs recommended to treat severe alcoholic hepatitis (sAH), with …

Liver fibrosis is a dynamic wound-healing response characterized by the agglutination of the
extracellular matrix (ECM). Si-Wu-Tang (SWT), a traditional Chinese medicine (TCM) …

Liver fibrosis (LF) is a dangerous clinical condition with no available treatment. Inflammation
plays a critical role in LF progression. Glucocorticoid-induced leucine zipper (GILZ, encoded …